Nielson Scientific LLC is in the business of developing advanced micro/nano-fabrication technologies that allow complete three-dimensional freedom to design and fabricate micro and nano-devices. The firm's technology is intended radically to impact industries involved in advanced silicon (and other semiconductor) microdevices such as MEMS sensors and actuators, silicon photonics, photonic crystals, metamaterials, microfluidics, and 3D chip integration. One of several examples of potential impact would be the Microfluidic devices are used in DNA analysis, clinical pathology, enzymatic analysis, proteomics, and other applications. The Nielson technology will allow variable cross-section and size channels (not just rectangular) routed three-dimensionally through the volume of the chip with the possibility for engineered semi-permeable membranes between channels.