SBIR-STTR Award

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Live therapeutics for prevention and control of necrotic enteritis associated with Clostridia perfringens in poultry
Award last edited on: 3/29/2021

Sponsored Program
SBIR
Awarding Agency
USDA
Total Award Amount
$756,500
Award Phase
2
Solicitation Topic Code
8.300000000000001
Principal Investigator
Yiannis Kaznessis

Company Information

General Probiotics Inc

1000 Westgate Drive Suite 150m
St Paul, MN 55114
   (612) 624-4197
   N/A
   www.gprobiotics.com
Location: Single
Congr. District: 04
County: Ramsey

Phase I

Contract Number: 2019-00932
Start Date: 7/29/2019    Completed: 3/31/2020
Phase I year
2019
Phase I Amount
$106,500
Necrotic enteritis in both its clinical and subclinical forms is a major health welfare and performance disease. Without technologies to control Clostridia perfringens (C. perf.) the causal agent of the disease producers are having a hard time to raise healthy birds and produce safe food. The challenge is now becoming acute with the withdrawal of antibiotics from livestock production. We propose to test a new class of safe probiotics that are equipped with antimicrobials that kill C.perf. With USDA support we will engineer 30 different modified probiotics against C. perf. We will test them and select the top performer to test in live birds. We hypothesize that modified probiotics can eliminate C. perf. and prevent necrotic enteritis in chickens. The proposed tests will provide the necessary proof of concept for further development. Our product will help chicken producers raise healthy birds reduce production losses and produce safe food. Our product can then help feed an increasing global population sustainably.

Phase II

Contract Number: 2020-06320
Start Date: 8/25/2020    Completed: 8/31/2022
Phase II year
2020
Phase II Amount
$650,000
Necrotic enteritis in both its clinical and subclinical forms is a major health welfare and performance disease. Without technologies to control Clostridia perfringens (C. perf.) the causal agent of the disease producers are having a hard time to raise healthy birds and produce safe food. The challenge is now becoming acute with the withdrawal of antibiotics from livestock production. We propose to test a new class of safe live thaerapeutics that are equipped with antimicrobials that kill C. perf. With USDA support we have previously engineered and tested modified probiotics demonstrating significant decrease in C. perf.-induced necrotic enteritis in poultry. We are proposing a series of experiments that will support the development plan for registration of antimicrobial probiotics by the FDA Center for Veterinary Medicine. Our product will help chicken producers raise healthy birds reduce production losses and produce safe food. Our product can then help feed the increasing global population sustainably.