
Biological Super-Resolution Imaging Using High-Index Microspheres for Cancer Research ApplicationAward last edited on: 11/13/2019
Sponsored Program
STTRAwarding Agency
NIH : NIGMSTotal Award Amount
$233,419Award Phase
1Solicitation Topic Code
-----Principal Investigator
Alejandro Carabe-FernandezCompany Information
Spherevis LLC
3401 Grays Ferry Avenue Building 212-118
Philadelphia, PA 19104
Philadelphia, PA 19104
Research Institution
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Phase I
Contract Number: ----------Start Date: ---- Completed: ----
Phase I year
2016Phase I Amount
$233,419Public Health Relevance Statement:
Public Health Relevance:
Microscopic imaging has traditionally been constrained by the diffraction limit, which for visible light restricts spatial resolution to ~250 nm. Surpassing thislimit would significantly benefit several disciplines, such as medical and material sciences. Our company, SphereVis LLC, has developed a simple generic super-resolution method for biological and photonic structures that provides two- to three-fold-enhancement in spatial resolution.
Project Terms:
Air; anticancer research; Area; Award; Barium; base; Biological; Biological Assay; Biological Sciences; Cancer Biology; Cancer cell line; Carbon ion; Cell Line; Cell Survival; Cells; Characteristics; Chemistry; Complex; cost; design; Development; diffraction of light; Discipline; economic cost; Elastomers; Equipment; field theory; Fluorescence Microscopy; fluorophore; Generic Drugs; Glass; global health; Goals; Image; image processing; imaging modality; Imaging Techniques; Immersion Investigative Technique; indexing; Individual; Investigation; Kinetics; Laws; lens; Light Microscope; materials science; Measures; Medical; Methods; Microfluidics; Microscope; microscopic imaging; Microscopy; Microspheres; Modality; molecular imaging; monolayer; nanoscale; Nobel Prize; novel; Optics; particle; Pattern; photonics; Photons; Positioning Attribute; Probability; Property; Protons; prototype; public health relevance; Radiation; Radiation Induced DNA Damage; Radiation therapy; Refractive Indices; repaired; Reporting; Research; Research Personnel; Resolution; Scanning; Scheme; Science; Semiconductors; Slide; Specimen; Specimen Handling; Spectrum Analysis; Structure; Surface; System; Techniques; Technology; Thick; Time; tool; Training; Translating; Visible Radiation
Phase II
Contract Number: ----------Start Date: ---- Completed: ----