Date: Nov 19, 2013 Source: (
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Milford, November 11, 2013. Spring Bank Pharmaceuticals, Inc. of Milford, MA today announced that Dr. Graham Foster from Queen Mary University of London, presented a Poster entitled "Pan-genotypic anti-HCV activity of SB9200 assessed in the ‘capture-fusion' replication assay' at the recently concluded conference of the American Association for the Study of Liver Diseases (AASLD) at Washington DC.
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Dr. Foster, a clinician and leader in the field of Hepatitis research has developed a novel model of HCV replication that is highly predictive of clinical outcome of potential antivirals. The capture fusion assay was used to assess the genotypic range of SB 9200, a clinical stage, host-targeted agent developed by Spring Bank for the treatment of Hepatitis C and Hepatitis B. In the capture-fusion assay, SB 9200 demonstrated potent antiviral activity against all the tested HCV genotypes 1a, 1b, 2, 3, 4 and 6. These results support the potential use of SB 9200 as a pan-genotypic, host-targeting anti-HCV agent that can be used with different classes of direct-acting antivirals in combination therapy. The results also support the novel mechanism of action of SB 9200 involving the activation of cellular viral sensors RIG-I and NOD2 for inducing antiviral state in cells.
