Date: Dec 05, 2014 Author: Matthew J. Wieduwilt, MD, PhD, University of California, San Diego Source: (
click here to go to the source)
San Carlos, CA December 5, 2014 - Cellerant Therapeutics Inc., announced that data from the Phase 1 clinical trial for CLT-008, a first-in-class, allogeneic, cell-based therapy for use in patients with acute myeloid leukemia (AML), will be presented at the 2014 American Society of Hematology (ASH) Annual Meeting and Exposition in San Francisco, December 6-9, 2014.
"We look forward to the opportunity to present clinical data on CLT-008 at ASH," said Ram Mandalam, Ph.D., President and Chief Executive Officer of Cellerant Therapeutics. "For AML patients with severe neutropenia, human myeloid progenitor cells (CLT-008) can proliferate and differentiate into myeloid effector cells with a potential to treat or prevent infection. Data from the study show clear evidence of safety. Efficacy signals are also present in the Phase 1 data with respect to reduction in mucositis and fever in patients receiving myeloablative chemotherapy for the treatment of AML."
Based on these positive Phase 1 results, Cellerant is initiating a multi-center, prospective, randomized Phase 2 clinical trial to demonstrate a decrease in risks of febrile episodes and infections related to chemotherapy treatment in AML. If successful, CLT-008 may also be applicable in many other clinical settings where chemotherapy-induced severe neutropenia is present.
The abstract and timing of the presentation is provided below:
Poster Presentation
Date: Sunday, December 7, 2014, 6:00 PM-8:00 PM
Location: North Building, Hall E (Moscone Center)
Abstract number: 2268
Presentation Title: Phase 1 Clinical Investigation of Human Myeloid Progenitor Cells (CLT-008) As a Supportive Care Measure during Chemotherapy for Acute Myeloid Leukemia (AML)
Presenting Author: Matthew J. Wieduwilt, MD, PhD, University of California, San Diego
Program: Oral and Poster Abstracts
Session: 613. Acute Myeloid Leukemia: Clinical Studies: Poster II
Abstract Link: https://ash.confex.com/ash/2014/webprogram/Paper67487.html
