Principals of the specific funded projects are with Mayo Clinic. Areas of expertise include Biofilm-mediated infections; Vancomycin-resistant enterococci and other vancomycin-resistant Gram positive organisms, including molecular epidemiology, therapy, clinical epidemiology and pathogenesis of such infections. Paenibacillus popilliae Mechanism of vancomycin-resistance in this vancomycin-resistant biopesticide. Novel approaches to prosthetic joint infection diagnosis. Novel antimicrobial agents for therapy of bacterial infections including in vitro studies and in vivo studies (rabbit endocarditis, mouse pneumonia, and rat osteomyelitis models), and human trials.