With technology leveraging modifications made to the degron region of HOX molecules to extend intracellular halflife, Ship of Theseus is described as developing a proprietary suite of enhanced HOX protein biologics (HOX+). HOX genes are master regulators of many context-specific cell phenotypes. Mnagement Describing advantages. management indicate "Shake and Bake" HOX proteins as difficult to target with cell or nuclear specificity and possessing an intracellular half-life on the order of minutes, requiring heavy, repeat dosing. HOX+ modified proteins enter cells within minutes of exposure and resist intracellular degradation for several days, reducing dose frequency and mass. In the clinical setting, HOX+ can be shipped and applied in situ rather than requiring ex vivo culture in a specialized facility.
