Sapere Bio Inc - formerly dba Healthspan DX. - was founded in 2013 by Dr. Norman "Ned" Sharpless and Dr. Natalia Mitin based on research undertaken at the Sharpless' lab at the Lineberger Cancer Center, University of North Carolina, Chapel Hill. Renamed in 2019, the firm has been a pioneer in the discovery of mechanisms of aging and predicted the role of senescence in human aging and chronic diseases, Pivotal work from the lab demonstrated a dual role for p16, a marker and regulator of senescence, in tumor suppression and aging. ? Building on this knowledge, Sapere Bio is conducting extensive clinical studies of aging biomarkers, including p16, in indications with high unmet need. The firm's technology supports measurement of physiologic reserve, guides clinical decisions, improves healthcare and save lives.