SBIR involved from soon after the firm was founded and still active in the program in three very different agencies - Air Force, Department of Energy and National Institutes of Health - RadiaSoft is a science consulting firm with roots in beam and accelerator physics research undertaking contract R&D for a range of clients: federal agencies, national labs, and universities. Developing open-source software for high-performance computing, principals of the firm provide cost effective research, data and software development to non-profit and commercial customers around the world. Current and past SBIR project topics have included high-energy physics simulation, particle accelerator control systems, proton cancer therapy modeling, and more. This range of projects have involved the firm's research scientists - experts in the parallel simulation of high-power beams, plasmas, laser pulses, and associated radiation sources. The firm's software development team designs intuitive browser-based GUIs for technical applications and has extensive expertise in wrapping legacy software via application containers. Consultants to the firm bring additional scientific or software expertise on demand. This combination of personnel require access to the right tools to be innovative, to make impactful discoveries. To thatend, RadiaSoft brought scientific computing to the cloud with Sirepo, the firm's open-source scientific framework - making possible high-quality scientific simulation codes accessible via browser-based GUIs.