In Spring 2022, Organix Inc was acquired by the Dutch firm Symeres, a European drug discovery firm. It is noted that the resulting business representa a truly differentiated transatlantic offering for the biopharma industry, with significant expertise in molecule design, synthesis, and early stage clinical manufacturing - with some three decades of experience in management of complex, multidisciplinary projects for both commercial and government clients in the areas of synthetic organic and medicinal chemistry, including chemistry related to biotechnology. Active in the SBIR space since the mid-nineties, Organix is licensed by the Drug Enforcement Agency and the Commonwealth of Massachusetts to conduct research and manufacture of controlled substances in Schedules 1 to 4 enabling the firm to provide Custom Synthesis of molecules in all structural classes; Design and Synthesis of New Chemical Entities; Structure Activity Relationship Studies; Hit-to-Lead Studies; and Development and Optimization of Synthetic Procedures; Custom synthesis of organic molecules; Optimization of existing synthetic methods; Structure Activity Relationship studies to discover new molecules and optimize lead compounds; Joint projects to discover and synthesize new molecular entities designed for specific functions; Discovery of new and more efficient approaches to the synthesis of target molecules; Synthesis of Libraries of Compounds; Preparation from milligram to kilogram quantities of compounds; and Characterization of components of complex organic mixtures. The company works in the synthesis of drug conjugates in which active new chemical entities (NCEs) are tethered to HRP, PEG, HPMA-polymers, HPMA-copolymers, or other large molecules. These tethered NCEs can also be designed to cleave and release the NCE in situ. Organix carries out syntheses of compounds on a scale which ranges from milligrams to a kilogram. These compounds span a wide array of organic chemistry and as such, scientists at Organix necessarily have a combined expertise in an extremely broad array of chemistry.
