Co-founded by two Emory university professors- in Atlanta, GA - NatGlycan, LLC is a biotech corporation focused on large-scale natural glycans. Principals of the firm have developed proprietary glycan extraction techniques that enable llarge scale preparation of natural glycans. The firm's proprietary process is based on a controlled oxidation using sodium hypochlorite (household bleach). Principals describe most natural glycans occuring as glycoconjugates - glycans are attached to other biomolecules such as proteins or lipids. Due to the high oxidation state of glycans, they are much more resistant to oxidative degradation than proteins and lipids including their linkages with glycans. As a result N-, O-glycans from glycoproteins and glycans from glycosphingolipids are quickly released by bleach with different reducing end structures and can be easily derivatized with fluorescent tags. Released N-, O- and GSL-glycans possess different reducing end structures and can be further derivatized for HPLC seperation
