Having been the first company to receive a "$1000 Genome" award from the National Human Genome Research Institute of the National Institutes of Health for an electronic approach to sequencing DNA, Nabsys uses proprietary electronic nano-channel detectors to analyze long DNA molecules at high velocity. Electronic detection enables Nabsys to achieve significantly higher resolution than can be obtained using optical mapping methods. Nabsys HD-Mapping solid-state electronic nano-channel detectors build whole genome maps with sub-diffraction-limit resolution that are truly high definition. These maps offer compelling advantages for the analysis of structural variation, the assembly of genomes, and as a method for confirming putative variants called using other technologies. HD-Mapping works by adding sequence-specific tags to long DNA molecules. These molecules pass through the nano-detectors at high velocity using a combination of electrophoretic and hydrodynamic control. The detectors report the locations of the sequence-specific tags on the molecules. The information is then analyzed by Nabsys analytical software. Key application areas that are enabled by Nabsys include: De Novo Assembly Structural Variant Discovery Variant Verification Microbiome Analysis Metagenome Characterization Hybrid Assembly Nabsys provides the complete solution for electronic genome mapping. The Nabsys HD-Mapping platform includes: HD-Mapping instrument Electronic nano-channel detector chips Complete run reagent cartridge Sample prep kit Comprehensive control and data analysis software. Nabsys HD Mapping provides routine, accurate, cost-effective analysis of genomic structural information. The HD-Mapping platform employs fully electronic detection of tagged single DNA molecules to provide significantly higher sensitivity, accuracy, scalability and speed of detection in comparison to existing mapping technologies. Single-molecule reads, hundreds of kilobases in length, have high resolution and low error rates, resulting in high information content per read.
