Generation Biotech provides tools for complex DNA analysis. Employing a methodology first used at Princeton University, to simplify the process while also making it more reliable, Experience in single molecule analysis and single nucleotide polymorphism (SNP) typing led to the development of a molecular enrichment and haplotyping method for separating the maternal and paternal copies from a patientÂ’s genomic DNA sample using magnetic particles. Originally ganized around adressing the issues of tissue-typing for organ donation, the rocess was commercialized in collaboration with GenoVision, Inc. The resulting HaploPrep product resolves all genotyping ambiguities found in the Human Leukocyte Antigen (HLA) gene region. Generation Biotech continues to develop new technologies for the separation of genomic DNA, DNA-associated proteins and specific cells. Region Specific Extraction (RSE) captures specific genomic regions of interest and is used for mapping copy number and location of viral insertions and transposable genetic elements. These technologies advance the efforts of disease association studies, whole genome re-sequencing efforts, QTL mapping and plant breeding. Experience in single molecule analysis and single nucleotide polymorphism (SNP) typing led to the development of a molecular enrichment and haplotyping method for separating the maternal and paternal copies from a patientÂ’s genomic DNA sample using magnetic particles.
