FocalCool is a medical device company working on the develoment of cooling catheters that are designed quickly to reduce tissue temperature, minimizing organ damage resulting from ischemia. While reperfusion therapy and stents have created paradigm shifts in interventional care, FocalCool aims to create another shift -- directly addressing myocardial reperfusion injury. is working on an endovascular regional cooler for the heart. The firm is seeking th be able rapidly to cool heart tissue during emergency angioplasty. Their new guide catheter - CoolGuide - maintains the functionality of standard guide catheters, providing coronary artery access for devices like angioplasty catheters and stents, while also delivering targeted chilled blood to heart tissue at risk. It is also thought that therapeutic hypothermia could improve lives by saving seemingly tiny amounts of tissue at risk, enabling vital organs to continue working well.