With obesity and type 2 diabetes now having reached epidemic proportions, Equator Therapeutics is addressing development of a very different approach to weight loss that is designed to increase metabolism and to burn calories without exercise. Addressing the root cause of metabolic disorders the imbalance between caloric intake and expenditure - Equator's approach is instead target mitochondria (the powerhouse of the cell) to generate heat -- an approach that has been proven to fully reverse obesity and type 2 diabetes in animals. Therapeutic application for humans was previously ineffective since mitochondrial heat production could only be induced by highly artificial methods with side effects. This recently changed with a breakthrough discovery of the protein that mitochondria naturally use to generate heat. Principals of Equator havenow developed a unique high-throughput drug discovery platform to identify compounds that selectively activate this target protein, without side effects.
