With a longer term focus on improved delivery and efficacy of nutraceuticals, vaccines, and therapeutics, near term BrioBiotech is initially focus is on aquaculture and animal applications - specifically, aquaculture vaccines such as infectious salmon anemia and infectious hematopoietic necrosis virus of salmonids. Oral vaccines promise easy delivery, reduced cost, a more rational vaccination regime (suitable for small, medium and large fish and can be combined in to the feed or provided as a food supplement). Oral vaccines must be delivered and pass through the gut then be released and taken up by cells that deliver the antigen to the appropriate immune system effector cells. This is a challenge being faced by oral vaccine developers in all systems (human, animal and aquaculture). However, oral vaccination in aquatic environments has a special set of challenges. Aquaculture oral vaccines need to be stabilized so they can be applied in open waters and be consumed by the fish. If they are incorporated into feeds, they must withstand processing temperatures, often steam, while maintaining their stability and efficacy. Many aquaculture facilities are located in high temperature and humid climates where operators are unable to keep feeds supplemented with vaccines or nutraceuticals in dry and cool conditions â stability is essentia
