BellBrook Labs develop high throughput screening assays for pharmaceutical industry. These assays assist in developing new drugs by allowing better predictions of how they will behave in clinical trials. The firm's leading products include: Transcreener® Biochemical Assay Technology - the latter being a bicohemical assay platform that enables screening of an entire family of convalent regulatory enzymes; e.g., kinases, with a single assay. Each Transcreener Assay provides a generic detection method for multiple enzyme families enabling the investigator to focus on evaluating new therapeutic strategies and optimizing lead molecules rather than on time-consuming assay development for individual targets. The AptaFluor™ SAH Methyltransferase Assay uses a natural occurring aptamer, or riboswitch, that selectively binds with SAH, the invariant product of methyltransferase reactions. The exquisite affinity and selectivity of the riboswitch combined with a positive TR-FRET signal enable screening and profiling of histone methyltransferases with unparalleled sensitivity.
