Company Profile

Aztek Bio LLC (AKA: KL50 Therapeutics LLC~Aztek~Aztek Bio Inc )
Profile last edited on: 11/19/2023      CAGE: 92PE8      UEI: EWKMDMMY8119

Business Identifier: Exploiting DNA repair defects to kill gliomas; plus GeoVax’s Ebola vaccine
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Location Information

36 Church Lane
Westport, CT 06880
   (203) 272-8658
Location: Single
Congr. District: 04
County: Fairfield

Public Profile

Originally dba as KL50 Therapeutics LLC, the firm was renamed Aztek in November 2021, then (a few months later) was announced as doing business as Aztek Bio Inc - jst soon after (in April 2022) was adjusted to Aztek Bio LLC. Yale School of Medicine scientists -- to include Azrec co-founders - revealed in the magazine Science compounds that target drug-resistant gliomas. Most glioma tumors lack the methyl transferase MGMT and initially respond to the DNA methylation agent temozolomide. Frequently, the cells acquire resistance through loss of the mismatch repair (MMR) pathway. Authorsof the article indicated having created agents that cause a dynamic DNA lesion via a two-step chemical process. The first lesion can be reversed by MGMT in healthy cells, but transforms into a more toxic secondary lesion in MGMT-deficient tumor cells, resulting in MMR-independent cell death.

Extent of SBIR involvement

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Synopsis: Awardee Business Condition

Employee Range
Revenue Range
Less than .5M
VC funded?
Privately Held
Stock Info
IP Holdings

Awards Distribution by Agency

Most Recent SBIR Projects

Key People / Management

  Ranjit S Bindra

  Seth Herzon

  Kingson Lin -- Co-Founder

Company News

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