Anchored in a growing understanding of the regulatory and signaling pathways responsible for cell growth, differentiation, and death, principals of Alphathera have been able to identify various anomalies in the genome and proteome that can be associated with disease. The interest is in developing molecular imaging probes that target these anomalies to locate and study diseased states in vivo. Probes are being developed that target a wide range of biological processes including gene regulation, mRNA localization, protein expression, and enzymatic activity. Multiple imaging platforms are used including magnetic resonance, fluorescence, and bioluminescence and applications range from studying the complex intracellular dynamics of individual cells to the early detection of disease in a clinical setting.
