Advanced Cooling Therapy, LLC, is developing improved methods to control patient temperature in order to more effectively implement mild therapeutic hypothermia, maintain operative normothermia, and treat fever. The firm's Esophageal Cooling Device (ECD) which received FDA clearance in June, 2015, incorporates a fully-enclosed coolant flow system, where two outer lumens are attached to commercially available heat exchange units typically used for water blankets, and an independent central lumen connects to wall suction that replaces the standard nasogastric or orogastric tube. The single use system is inserted into the esophagus to modulate and control patient temperature when clinically indicated. The capability also extends to enabling a number of additional clinical uses, including the incorporation of esophageal manometry to guide ventilator management, gastric tonometry to diagnose abdominal compartment syndrome, pH measurements and parenteral medication administration
