Founded by a Purdue University assistant professor and anassociate, Adipo Therapeutics is developing a disruptive technology platform involving use of polymer-based nanoparticulate drug delivery systems to induce adipocyte browning as a safe and effective therapeutic solution to treat obesity. Adipocyte browning is usefully understood as converting energy-storing bad fat cells into energy-burning good fat cells in the body. The innovation combines the recent discovery of the role played by Notch signaling in adipocyte plasticity with advances in polymer-based drug delivery. This technology offers several unique value propositions including sustainable weight loss, improved glucose homeostasis and systemic metabolism - all with minimal off-target side effects. Such an enabling technology platform also has the potential for ready adaption to treat a broad spectrum of diseases such as fatty liver disease and atherosclerosis
