Skip to main content
idi
Toggle navigation
0
You have 0 notifications
Site Visitor
Site Visitor
New To Inknowvation.com?
Register now to get an access to proprietary SBIR-STTR databases!
Registration is fast and free - start your access to business-actionable information today!
Login
Site Register
SBIR-STTR Award
You are here:
Home
Search Databases
Search SBIR-STTR Awards
SBIR-STTR Award
3
Strain-level diagnostics of fungal crop pathogens enabled by fully-phased isolate genomes
Award last edited on: 5/31/22
Sponsored Program
SBIR
Awarding Agency
USDA
Total Award Amount
$99,866
Award Phase
1
Solicitation Topic Code
8.130000000000001
Principal Investigator
Ivan Liachko
Company Information
Phase Genomics Inc
1617 8th Avenue N
Seattle, WA 98109
(206) 384-6228
info@phasegenomics.com
www.phasegenomics.com
Location:
Single
Congr. District:
07
County:
King
Phase I
Contract Number:
2021-00641
Start Date:
3/17/21
Completed:
5/31/22
Phase I year
2021
Phase I Amount
$99,866
Fungal rust pathogens are a major threat to the global food supply chain. Oat crown rust canhave a devastating impact of oat production leading to losses as high as 35% in South Dakota and50% in Minnesota in 2014.Understanding their spread evolution and virulence requires a deeperlevel of genomic information than we currently possess.Despite current surveillance activities andample rust collections in various countries there has been a lag in the development of moleculardiagnostic tools. Pilot studies using the wheat stripe rust pathogen demonstrate ability to trace rustisolates to the lineage level and fail to provide strain-specific information.One of the mainchallenges in understanding many rust genomes is their complex (dikaryotic) nature where strainscontain genomic information from two independent nuclei. It has also been demonstrated that theevolution of virulence could be mediated by hybridization events between two rust strains (e.g.emergence of the wheat stem rust Ug99) adding to the complex genomic structure and presentingsignificant obstacle to genetic analysis and diagnostics.Using cutting edge genomic tools it is nowpossible and affordable to generate full chromosome-scale rust genomes and separate theirconstituent sub-genomes as was demonstrated by the wheat stem rust pathogen.We propose toapply this methodology to a set of diverse oat crown rust isolates in order to develop a referencelibrary of fully-phased chromosome-scale genomes that will be used as a foundation forsurveillance diagnostics and will enable the identification of novel virulence factors. The ability toleverage high-quality genomic information from sets of rust strains will transform our ability totrack their spread and understand the evolution of fungal virulence.
Phase II
Contract Number:
----------
Start Date:
00/00/00
Completed:
00/00/00
Phase II year
----
Phase II Amount
----
×
Login to your account
Mail sent successfully.
Enter any username and password.
Username
Password
Remember me
Login
Forgot your username?
Click here for assistance
Forgot your password?
Request new password
Don't have an account?
Sign up
Forgot username?
Mail sent successfully.
Enter username and password.
Please enter email address that is associated with your account.
Back
Submit
Still Need Help?
If you need further assistance, send us an
e-mail
and we will assist you in resetting your account.
Forgot password?
Mail sent successfully.
Enter username and password.
Please enter email address that is associated with your account.
Back
Submit
Still Need Help?
If you need further assistance, send us an
e-mail
and we will assist you in resetting your account.