SBIR-STTR Award

Natural biodegradable flocculants derived from hemoglobin
Award last edited on: 3/29/2021

Sponsored Program
SBIR
Awarding Agency
USDA
Total Award Amount
$700,000
Award Phase
2
Solicitation Topic Code
8.4
Principal Investigator
David Meisinger

Company Information

VRM Labs inc (AKA: VRMLABS)

102 Ash Court
Easley, SC 29642
   (515) 975-3557
   info@vrmlab.com
   www.vrmlab.com
Location: Single
Congr. District: 03
County: Pickens

Phase I

Contract Number: 2016-33610-25439
Start Date: 8/1/2016    Completed: 6/30/2017
Phase I year
2016
Phase I Amount
$100,000
Antioxidants are a vital component of the food industry. Most of currently used antioxidants are synthetic chemicals, and there is a global concern among regulatory bodies and customers regarding the safety of these compounds. However, natural antioxidants are more than ten times more expensive, and are often not as effective as their synthetic counterparts. Thus, there is a need for inexpensive and capable natural antioxidants. In response to this need, we have developed a novel, simple, and cheap method for extraction of natural, safe, and effective antioxidants from animal blood, a source available in large quantities as a co-product from the animal and poultry processing industry. We have shown these novel antioxidants are as efficient as currently used synthetic antioxidants in several food models. Perhaps even more compelling is the low cost of production, which is several times cheaper than that for most of the synthetic competitors, and 25-50 times cheaper than that for natural antioxidants. The long-term goal of this project is to develop an inexpensive natural antioxidant to be used as a human food preservative. During the Phase I, we will focus on collecting the proof-of-concept performance and safety data for our prototype product. Studies performed during the Phase I will address 1) Comparison performance of our product to that of most common synthetic and natural antioxidants and optimization of the treatment dose; 2) Study of the mechanism of antioxidant activity; and 3) Assessment of susceptibility to microbial contamination. This project will further advance methods of extraction and characterization of antioxidants from animal/poultry blood and provide better insight on their safety and susceptibility to bacterial contamination. This study will also advance knowledge about performance and stability of antioxidants extracted in partially purified form, in a mixture with other blood components

Phase II

Contract Number: 2017-33610-27011
Start Date: 9/1/2017    Completed: 8/31/2019
Phase II year
2017
Phase II Amount
$600,000
VRM Labs is seeking commercialization of a proprietary technology that allows preparation of a novel natural and biodegradable flocculant. Flocculants are substances, which destabilize colloidal suspensions and promote the clumping and settling of the suspended particles. Among the most important applications of flocculants is treatment of agricultural wastewaters, such as the wastewaters generated in livestock slaughter and processing plants, rendering plants, etc. Flocculants are also directly applied to soil to prevent erosion in agricultural and construction areas. Most of the currently used flocculants are synthetic and their application in large scale agriculturally-related processes is becoming a growing concern for consumers, public, and regulatory entities due to their lack of biodegradability and potential toxicity of accumulated contaminants. Successful development of a highly efficient biodegradable flocculant will help to address these concerns and provide an environmentally friendly way for treatment of wastewaters generated in agricultural processes. Successful development of a highly efficient biodegradable flocculant will lead to improved methods for reuse of wastewater because currently available methods rely primarily on the use of potentially harmful synthetic flocculants. Flocculants are widely used in agriculture for clarifying livestock slaughter and rendering waste liquids and in many other applications throughout agriculture, mining, and construction. The flocculants of choice by the livestock and rendering industries are often synthetic polymers, most commonly derivatives of polyacrylamide (PAM).While these synthetic flocculants are attractive due to their high effectiveness and low cost, there is growing concern about the environmental and health impacts of these substances. Consequently, much attention, both in industry and in academia, is currently paid to the development of bio-based alternatives to synthetic polymer flocculants. Dr. Garcia and co-workers, from a USDA/ARS lab, recently discovered that hemoglobin can function as a powerful biodegradable flocculant suitable for wastewater recovery. The long-term goal of this work is to develop and commercialize a cost-efficient biodegradable hemoglobin-based flocculant. During the Phase I stage we demonstrated the proof-of-concept and developed a lab-scale prototype, which was found to be an efficient flocculant with both laboratory models and real-life industrial wastewaters. We also performed market research, which resulted in favorable assessment of the feasibility of successful commercialization of this USDA-owned technology. The objective of the proposed Phase II work is the development of a scaled up process for manufacturing of our flocculant and its detailed large scale testing at industrial wastewater treatment facilities.The following Specific Aims are proposed to achieve these goals: 1) Lab-scale optimization of the manufacturing process to achieve the most cost-effective formulation; 2) Detailed small scale efficacy studies (jar testing) at several industrial settings with the emphasis on post-treatment wastewater quality; 3) Scaling up of the manufacturing process; and 4) Large-scale testing of our flocculant at rendering wastewater treatment facilities. VRM Labs team will be responsible for manufacturing of the flocculant, scaling up and testing in industrial settings and ARS team will be responsible for detailed studies of performance of our flocculant in laboratory setting.