SBIR-STTR Award

Integrated Single and Parallel Channel Sorting Cytometer Employing Novel Detection Methods
Award last edited on: 3/21/2002

Sponsored Program
SBIR
Awarding Agency
NSF
Total Award Amount
$237,835
Award Phase
2
Solicitation Topic Code
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Principal Investigator
James F Brown

Company Information

Cytonix (AKA: Cyto Fluidics Inc)

8000 Virginia Manor Road
Beltsville, MD 20705
   (301) 470-6267
   emailbox@cytonix.com
   www.cytonix.com
Location: Single
Congr. District: 05
County: Prince Georges

Phase I

Contract Number: 8760730
Start Date: 00/00/00    Completed: 00/00/00
Phase I year
1987
Phase I Amount
$50,000
Cellular biology research has benefitted from the technological advances made in cytometry. This company will utilize its patented "fluid resistor" to produce an instrument with microchannels and valves small enough to sort cells individually. This will allow not only fluid sorting but also stopped-flow image analysis of individual cells. Potentially this instrument will be less expensive than current cell sorters because less costly light sources can be used if the analysis time can be increased. That would make this important technology available to more research facilities. Phase I will consist of improving the geometry of the channels, decreasing valve cycle time, and testing the system using particles and cells.

Phase II

Contract Number: 8822197
Start Date: 00/00/00    Completed: 00/00/00
Phase II year
1989
Phase II Amount
$187,835
This award provides funds for a Small Business Innovation Research Phase II award. Investigation of integrated single and parallel channel stopped-flow, sorting cytometers will be carried out, employing novel detection methods and fluid control elements. The single channel cytometer will correlate simultaneous measurements of Coulter volume and fluorescence with high resolution images and impedance-based immunological quantification. The parallel channel cytometer will measure Coulter volume and two immunological parameters concurrently on three flow channels. Both cytometers should sort at 100 to 500 cells/second per channel as determined by Coulter volume and two fluorescence-equivalent parameters.