The Centers for Disease Control and Prevention (CDC) and National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP) currently use various technologies for integrating public health and pharmacy data, each with specific limitations. This includes centralized data repositories, legacy communication protocols like HL7 2.x, data warehouses with batch processing, point-to-point integration models, and manual data entry systems. These systems face challenges such as data inaccessibility, inadequate web-based interactions, delayed data updates, complex and costly maintenance, and error-prone manual processes. Our proposes a novel software solution focusing on pharmacist eCare software add-ons to address these challenges. This approach aims to enhance information sharing and establish a dynamic, responsive, patient-oriented public health infrastructure. Critical features of Neoskyes proposal include interoperability and integration through System APIs, adoption of modern API protocols like FHIR, real-time data processing for rapid public health responses, architectural simplicity, automation for improved efficiency, scalable infrastructure, enhanced user experience, and robust security and compliance measures. Our novel software aligns with healthcare data exchange standards, implementing advanced security protocols for data privacy and developing the API to support real-time data transactions and scalability.