
Time-resolved laser speckle contrast imaging of resting-state functional connectivity in neonatal brainAward last edited on: 3/5/2025
Sponsored Program
SBIRAwarding Agency
NIH : NIMHTotal Award Amount
$1,218,635Award Phase
2Solicitation Topic Code
242Principal Investigator
Guoqiang YuCompany Information
Biopticstechnology LLC (AKA: Bioptics Technology LLC)
2236 Barnwell Lane
Lexington, KY 40513
Lexington, KY 40513
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Location: Single
Congr. District: 06
County: Fayette
Congr. District: 06
County: Fayette
Phase I
Contract Number: 1R42MH135825-01Start Date: 8/1/2023 Completed: 7/31/2024
Phase I year
2023Phase I Amount
$289,075Public Health Relevance Statement:
Project narrative:
Continuous monitoring of neonatal brain development is crucial for effective management of brain injury and associated complications, thus reducing healthcare burden and costs. Bioptics Technology is developing, validating, and commercializing a revolutionary time-resolved laser speckle contrast imaging (TR-LSCI) technology that enables noncontact, fast, high-resolution imaging of cerebral blood flow and resting-state functional connectivity across distinct regions of the brain for noninvasive and continuous assessment of neonatal brain development to prevent brain injury. While the proposal tests this imaging technology in perinatal hypoxic-ischemic encephalopathy models of neonatal rats and piglets as the first step for preclinical commercialization, the TR-LSCI device is broadly applicable to investigate many neurovascular diseases beyond HIE occurring in human neonates, thereby providing a significant opportunity for future clinical development and commercialization.
Project Terms:
Phase II
Contract Number: 4R42MH135825-02Start Date: 8/1/2024 Completed: 7/31/2026
Phase II year
2024Phase II Amount
$929,560Public Health Relevance Statement:
NARRATIVE Continuous monitoring of neonatal brain development is crucial for effective management of brain injury and associated complications, thus reducing healthcare burden and costs. Bioptics Technology is developing, validating, and commercializing a revolutionary time-resolved laser speckle contrast imaging (TR-LSCI) technology that enables noncontact, fast, high-resolution imaging of cerebral blood flow and resting-state functional connectivity across distinct regions of the brain for noninvasive and continuous assessment of neonatal brain development to prevent brain injury. While the proposal tests this imaging technology in perinatal hypoxic-ischemic encephalopathy models of neonatal rats and piglets as the first step for preclinical commercialization, the TR-LSCI device is broadly applicable to investigate many neurovascular diseases beyond HIE occurring in human neonates, thereby providing a significant opportunity for future clinical development and commercialization. Terms: <3-D; 3-Dimensional; 3D; Acquired brain injury; Affect; Algorithms; Animal Model; Animal Models and Related Studies; Biological Markers; Body Tissues; Brain; Brain Injuries; Brain Nervous System; Brain hemodynamics; Brain imaging; Brain region; Calibration; Cell Communication and Signaling; Cell Signaling; Cerebrovascular Circulation; Clinical; Collaborations; Common Rat Strains; Complex; Consumption; Development; Diffuse; Diffusion; Disease; Disorder; EEG; Early Diagnosis; Electroencephalogram; Electroencephalography; Encephalon; Fullterm Birth; Functional MRI; Functional Magnetic Resonance Imaging; Future; Head; Health; Human; Image; Imaging Device; Imaging Instrument; Imaging Tool; Imaging technology; Infant; Intracellular Communication and Signaling; Investigation; Kentucky; Laboratories; Laser Speckle Imaging; Light; MR Imaging; MR Tomography; MRI; MRIs; Magnetic Resonance Imaging; Maps; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods; Modality; Modeling; Modern Man; Monitor; NIR Spectroscopy; NMR Imaging; NMR Tomography; Near-Infrared Spectrometry; Near-Infrared Spectroscopy; Neonatal; Neonatal Brain Injury; Neonatal Intensive Care Units; Neurodevelopmental Problem; Neurosciences Research; Newborn Intensive Care Units; Noise; Nuclear Magnetic Resonance Imaging; Operating System; Outcome; PET; PET Scan; PET imaging; PETSCAN; PETT; Pathology; Perinatal Hypoxic-Ischemic Encephalopathy; Perinatal anoxic ischemic brain injury; Phase; Photons; Photoradiation; Physiologic pulse; Positron Emission Tomography Medical Imaging; Positron Emission Tomography Scan; Positron-Emission Tomography; Probabilistic Models; Probability Models; Property; Pulse; Rad.-PET; Rat; Rats Mammals; Rattus; Resolution; Rest; Risk; Rodent; Rodentia; Rodents Mammals; STTR; Scalp; Scalp structure; Signal Transduction; Signal Transduction Systems; Signaling; Skull; Small Business Technology Transfer Research; Statistical Models; System; Technology; Term Birth; Testing; Time; Tissues; Universities; Variant; Variation; Zeugmatography; bio-markers; biologic marker; biological signal transduction; biomarker; biomarker identification; blood flow in brain; brain abnormalities; brain blood circulation; brain blood dynamics; brain blood flow; brain damage; brain visualization; brain-injured; care costs; cerebral blood flow; cerebral circulation; cerebral hemodynamics; cerebrocirculation; cerebrovascular blood flow; clinical applicability; clinical application; clinical development; commercialization; cost; cranium; de-noising; denoising; design; designing; developmental; diffuse optical tomography; diffused; diffuses; diffusing; diffusions; early detection; experiment; experimental research; experimental study; experiments; fMRI; feasibility testing; full-term birth; fullterm newborn; healthcare burden; high resolution imaging; hypoxic ischemic encephalopathy; identification of biomarkers; identification of new biomarkers; imager; imaging; improved; in vivo; laser speckle contrast imaging; lens; lenses; marker identification; model of animal; mortality; neonatal HIE; neonatal ICU; neonatal brain; neonatal brain development; neonatal hypoxia-ischemia; neonatal hypoxic-ischemic brain injury; neonatal hypoxic-ischemic encephalopathy; neonate; neural imaging; neuro-imaging; neuro-vascular; neuroimaging; neurological imaging; neurovascular; operation; operations; pig model; piglet model; porcine model; portability; positron emission tomographic (PET) imaging; positron emission tomographic imaging; positron emitting tomography; pre-clinical; preclinical; prevent; preventing; prototype; reconstruction; resolutions; statistical linear mixed models; statistical linear models; swine model; term newborn; three dimensional; tomography; user-friendly