
Single-molecule protein sequencing by barcoding of N-terminal amino acidsAward last edited on: 2/10/2024
Sponsored Program
SBIRAwarding Agency
NIH : NIGMSTotal Award Amount
$358,981Award Phase
1Solicitation Topic Code
859Principal Investigator
Daniel M EstandianCompany Information
Glyphic Biotechnologies Inc
169 Madison Avenue Suite 2216
New York, NY 10016
New York, NY 10016
(925) 477-7334 |
letschat@glyphic.bio |
www.glyphic.bio |
Location: Single
Congr. District: 15
County: San Mateo
Congr. District: 15
County: San Mateo
Phase I
Contract Number: 1R43GM151897-01Start Date: 9/15/2023 Completed: 9/14/2024
Phase I year
2023Phase I Amount
$358,981Public Health Relevance Statement:
NARRATIVE No current technology is capable of sequencing individual proteins from beginning to end. Glyphic Biotechnol- ogies plans to develop a novel method of single-molecule protein sequencing, which will bring improvements analogous to those of Next-Generation Sequencing of DNA. The Glyphic protein sequencing technology will allow high-throughput, simultaneous sequencing of millions of proteins from samples as small as single cells.
Project Terms:
Data; Detection; Protein Analysis; Resolution; resolutions; Process; protein function; next generation; nano pore; nanopore; cost effective; pathogen; NH2-terminal; N-terminal; Coupled; innovate; innovative; innovation; C-terminal; commercialization; bio-markers; biologic marker; biomarker; Biological Markers; NGS Method; NGS system; next gen sequencing; nextgen sequencing; next generation sequencing; High-Throughput Sequencing; High-Throughput Nucleotide Sequencing; global gene expression; global transcription profile; transcriptome; medical diagnostic; clinical diagnostics; DNA seq; DNAseq; DNA sequencing; Acceleration; Acids; Affect; Primary Protein Structure; protein sequence; Amino Acid Sequence; aminoacid; Amino Acids; Antibodies; Bar Codes; barcode; Biology; Biotechnology; Biotech; Blood; Blood Reticuloendothelial System; Buffers; Cells; Cell Body; Charge; Chemistry; High Pressure Liquid Chromatography; HPLC; High Performance Liquid Chromatography; High Speed Liquid Chromatography; Disease; Disorder; DNA; Deoxyribonucleic Acid; Face; faces; facial; Future; Gel; Genome; Growth and Development function; Growth and Development; Libraries; Light; Photoradiation; Methods; Parents; parent; Peptide Mapping; Peptide Fingerprinting; Peptides; Proteins; Reagent; Research; Rest; RNA; Non-Polyadenylated RNA; RNA Gene Products; Ribonucleic Acid; Signal Transduction; Cell Communication and Signaling; Cell Signaling; Intracellular Communication and Signaling; Signal Transduction Systems; Signaling; biological signal transduction; Specificity; Mass Spectrum Analysis; Mass Photometry/Spectrum Analysis; Mass Spectrometry; Mass Spectroscopy; Mass Spectrum; Mass Spectrum Analyses; Technology; bases; base; improved; biologic; Biological; Link; Chemicals; Individual; Dysfunction; Physiopathology; pathophysiology; Functional disorder; Hour; Complex; Side; Reaction; System; gel electrophoresis; molecular mass; Structure; novel; Basic Science; Basic Research; Positioning Attribute; Position; Protein Sequence Analysis; Amino Acid Sequence Analyses; Amino Acid Sequence Analysis; Peptide Sequence Analyses; Peptide Sequence Analysis; Protein Sequence Analyses; Peptide Sequence Determination; Amino Acid Sequence Determinations; Protein Sequence Determinations; Protein Sequencing; Protein Sequencing Molecular Biology; Proteome; Sampling; drug development; Proteomics; single molecule; Protein Secretion; Molecular Interaction; Binding; Complex Mixtures; magnetic beads; Polymerase; Address; Affinity
Phase II
Contract Number: ----------Start Date: 00/00/00 Completed: 00/00/00