Sepsis, the systemic manifestation of infection, causes complex and costly hospitalizations with unacceptably high morbidity and mortality. Most research focuses on detection of the sepsis within the hospital; however, most sepsis is community-acquired and thus begins in the home. Nightingale Labs has developed a fully automated non-contact home bed sensing platform that detects signatures of hospitalizations without requiring any patient participation. Here, we will test whether the technology can be used to detect infections or sepsis. This SBIR proposal will evaluate the feasibility (Phase 1) and execute (Phase 2) a prospective observational study to learn the signatures of impending hospitalizations for localized or systemic infection. The work will substantially expand the toolkit for facilitating early recognition and intervention to reduce infection- and sepsis-associated morbidity and mortality.
Public Health Relevance Statement: PROJECT NARRATIVE Sepsis is a costly and often fatal condition that results from spread of localized infections. In the hospital, early detection of sepsis makes it possible to start antibiotics sooner and improve outcomes; however, most sepsis begins outside of the hospital, in the home. This proposal aims to use sensors in the home bed to recognize early signs of infections and sepsis and to improve care.
Project Terms: Antibiotic Agents; Antibiotic Drugs; Miscellaneous Antibiotic; Antibiotics; Automation; Beds; Blood; Blood Reticuloendothelial System; Charge; Clinic Visits; Communication; Communities; Dehydration; body water dehydration; Dialysis procedure; Dialysis; dialysis therapy; Focal Infection; infection localized; local infection; Gastrointestinal Hemorrhage; GI bleeding; GI hemorrhage; gastrointestinal bleeding; Goals; Heart failure; cardiac failure; hospice environment; Hospices; Hospitalization; Hospital Admission; Hospitals; Infection; Intelligence; Learning; Mattresses; Morbidity - disease rate; Morbidity; mortality; Outpatients; Out-patients; Patient Participation; Patients; Pneumonia; Research; Risk; Septic Shock; Technology; Testing; Thoracic Radiography; CXR; chest X ray; chest Xray; chest radiography; lung radiography; radiographic chest image; radiographic lung image; thoracic radiogram; thorax radiography; Travel; Urine; Work; Measures; Caring; sensor; improved; Clinical; Phase; Hospitalization cost; Hospital Costs; Evaluation; Early Intervention; participant recruitment; Patient Recruitments; Systemic infection; Contracts; Contracting Opportunities; Diagnostic; Notification; Hour; Frequencies; Complex; Event; Cardiopulmonary; Early Diagnosis; early detection; Devices; Reporting; Admission activity; Admission; response; Intervention; Intervention Strategies; interventional strategy; actigraph; actigraphy; ESRD; End-Stage Kidney Disease; End-Stage Renal Disease; End stage renal failure; Health system; Symptoms; Adherence; Data; Detection; Cardiopulmonary Physiology; Enrollment; enroll; Observational Study; Observation research; Observation study; Observational research; Small Business Innovation Research Grant; SBIR; Small Business Innovation Research; Monitor; Process; Home visitation; House Call; home visit; cost; designing; design; blood infection; bloodstream infection; Sepsis; Outcome; blind; Population; prospective; anti-microbial; antimicrobial; patient population; population health; improved outcome; dashboard; recruit; wearable electronics; wearable system; wearable technology; wearable tool; wearables; wearable device; service organization; sleep pattern; data ingestion; detection system; detection platform; feasibility testing; homes; Home; Chronic Obstructive Pulmonary Disease; COPD; Chronic Obstruction Pulmonary Disease; Chronic Obstructive Lung Disease; observational cohort study
