
Development of lysosome targeted therapeuticsAward last edited on: 3/8/2023
Sponsored Program
STTRAwarding Agency
NIH : NCITotal Award Amount
$258,341Award Phase
1Solicitation Topic Code
395Principal Investigator
Jennifer CarewCompany Information
Majestic Therapeutics LLC
5931 E Finisterra
Tucson, AZ 85750
Tucson, AZ 85750
(520) 626-2272 |
N/A |
N/A |
Research Institution
University of Arizona
Phase I
Contract Number: 1R41CA271967-01Start Date: 7/1/2022 Completed: 6/30/2023
Phase I year
2022Phase I Amount
$258,341Public Health Relevance Statement:
PROJECT NARRATIVE Patients with acute myeloid leukemia (AML) have a dismal prognosis and new therapeutic approaches are desperately needed. Our preliminary studies have identified the lysosomal proteolysis pathway as a selective target for AML therapy. Here, we propose to optimize the pharmacological properties of our lead hit orally active lysosomal disrupting agent to identify a lead compound that is a candidate for commercialization.
Project Terms:
Phase II
Contract Number: ----------Start Date: 00/00/00 Completed: 00/00/00