Magnetic resonance imaging (MRI) is critically important for pediatric care and the unusable data caused by patient motion has been estimated to cost $1.4B per year in the United States alone. Currently, a radiologist assesses if the images are satisfactory or not, but an MRI technologist does the imaging, and coordination of communication between the two is costly and slow. We propose to develop a device that monitors motion during an MRI scan without creating an MRI artifact or posing a burden to the subject. We propose to develop and assess a device based on MRI compatible MEMS technology that will measure motion and allow an MRI technologist to intervene to improve image quality by reminding the subject to hold still, and to assess the final image quality associated with the imaging data acquired. This will save valuable imaging time and reduce costs by improving the rate of diagnostic quality images, and save time by assisting the MR technologist to decide if the images are sufficient or if they need to be repeated. In this Phase I study, we will develop and validate an MRI compatible gyroscope and an MRI compatible magnetic field sensor, which in combination with an existing MRI compatible accelerometer will allow for rapid calibration of the device to the MRI coordinate system and the sensing of six degree of freedom motion. BIOPAC currently makes and sells an MRI compatible accelerometer. We will develop an MRI compatible gyroscope and magnetometer and a combined MRI compatible accelerometer/gyroscope in the same form factor as the current accelerometer. The sensor measurements will be converted to a digital signal through the existing BIOPAC MP160 hardware interface. We will write a software interface to enable each sensor to be used with the BIOPAC AcqKnowledge data acquisition software. These sensors will then be tested for their ability to operate safely in a clinical 3T MRI environment, tested for their ability to not create artifacts due to either RF interference or magnetic susceptibility changes, and tested for the accuracy of the sensor measurements in the MRI. Public Health Relevance Statement Narrative Magnetic resonance imaging (MRI) is critically important for pediatric care and the unusable data caused by patient motion has been estimated to cost $1.4B per year in the United States alone. Currently, a radiologist assesses if the images are satisfactory or not, but an MRI technologist does the imaging, and coordination of communication between the two is costly and slow. We propose to develop an MRI compatible MEMS device that monitors motion during an MRI scan in order to assist the MRI technologist to see motion while it is occurring, to intervene to mitigate motion while the imaging is being acquired, and to determine if the final images formed are of diagnostic quality or not. This will save valuable imaging time and reduce costs by improving the rate of diagnostic quality images, and save time by assisting the MR technologist to decide if the images are sufficient or if they need to be repeated.
Project Terms: Acceleration ; Anesthesia procedures ; Anesthesia ; Animals ; Back ; Dorsum ; Behavior Therapy ; Behavior Conditioning Therapy ; Behavior Modification ; Behavior Treatment ; Behavioral Conditioning Therapy ; Behavioral Modification ; Behavioral Therapy ; Behavioral Treatment ; Conditioning Therapy ; behavior intervention ; behavioral intervention ; Calibration ; Child ; 0-11 years old ; Child Youth ; Children (0-21) ; youngster ; Communication ; Environment ; Equipment ; Feedback ; Freedom ; Liberty ; Future ; Head ; Heating ; Human ; Modern Man ; Kinetics ; Lead ; Pb element ; heavy metal Pb ; heavy metal lead ; Magnetic Resonance Imaging ; MR Imaging ; MR Tomography ; MRI ; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance ; NMR Imaging ; NMR Tomography ; Nuclear Magnetic Resonance Imaging ; Zeugmatography ; Motion ; Patients ; Risk ; Safety ; Signal Transduction ; Cell Communication and Signaling ; Cell Signaling ; Intracellular Communication and Signaling ; Signal Transduction Systems ; Signaling ; biological signal transduction ; Computer software ; Software ; Technology ; Testing ; Time ; United States ; Work ; Writing ; ferrite ; ferromagnets ; ferrospinel ; Measures ; Morphologic artifacts ; Artifacts ; Caring ; base ; sensor ; improved ; Clinical ; Phase ; Ensure ; Predisposition ; Susceptibility ; Training ; Childhood ; pediatric ; Measurement ; radiologist ; Force of Gravity ; Gravities ; tool ; sedation ; Sedation procedure ; Diagnostic ; Knowledge ; programs ; Severities ; Scanning ; Pattern ; System ; magnetic ; Magnetism ; magnetic field ; monitoring device ; Performance ; success ; Devices ; Reporting ; Magnetic Resonance Imaging Scan ; MRI Scans ; Data ; Collection ; Monitor ; transmission process ; Transmission ; Image ; imaging ; vector ; cost ; digital ; software systems ; data acquisition ; safety testing ; phase 1 study ; Phase I Study ; rate of change ; Accelerometer ; accelerometry ; activity monitor ; activity tracker ; motion sensor ;
