
Optimization of a Novel Thread Geometry for Various Orthopedic Surgery ApplicationsAward last edited on: 2/16/2024
Sponsored Program
SBIRAwarding Agency
NIH : NIAMSTotal Award Amount
$1,314,888Award Phase
2Solicitation Topic Code
846Principal Investigator
Andrew R FauthCompany Information
OsteoCentric Technologies Inc (AKA: SMV Scientific LLC~Summit Med Ventures)
111 Sandra Muraida Way Unit 18A
Austin, TX 78703
Austin, TX 78703
(800) 969-0639 |
info@osteocentric.com |
www.osteocentric.com |
Location: Single
Congr. District: 25
County: Travis
Congr. District: 25
County: Travis
Phase I
Contract Number: 1R44AR079300-01A1Start Date: 9/20/2021 Completed: 8/31/2024
Phase I year
2021Phase I Amount
$1,104,366Public Health Relevance Statement:
PROJECT NARRATIVE The threaded screws used in orthopaedic surgery share a common buttress design that has intrinsic weaknesses, potentially increasing the risk of postoperative complications. OsteoCentric has developed a novel thread-interface technology designated Bone Interlocking Thread Geometry (BITG) which seeks to mitigate these weaknesses. We have sought to optimize BITG after validating a bone-thread-interface Finite Element model. This SBIR Phase II proposal will continue with design optimization, followed by a large animal model study and optimization of the manufacturing methodology for the new thread geometry.
Project Terms:
Activities of Daily Living; Activities of everyday life; daily living functionality; functional ability; functional capacity; Anatomy; Anatomic; Anatomic Sites; Anatomic structures; Anatomical Sciences; Animals; Architecture; Engineering / Architecture; bone; Bone Screws; Clinical Research; Clinical Study; cost effectiveness; Education; Educational aspects; Elements; Equipment; Face; faces; facial; Fatigue; Lack of Energy; Fracture; bone fracture; Future; Patient Care; Patient Care Delivery; Goals; Healthcare Systems; Health Care Systems; Histology; Human; Modern Man; Israel; Lead; Pb element; heavy metal Pb; heavy metal lead; Methods; Methodology; Study models; Orthopedics; Orthopedic; Orthopedic Surgical Profession; Patients; Postoperative Complications; post-operative complications; Production; research and development; Development and Research; R & D; R&D; Risk; Sheep; Ovine; Ovis; Stress; Technology; Testing; Time; X-Ray Computed Tomography; CAT scan; CT X Ray; CT Xray; CT imaging; CT scan; Computed Tomography; Tomodensitometry; X-Ray CAT Scan; X-Ray Computerized Tomography; Xray CAT scan; Xray Computed Tomography; Xray computerized tomography; catscan; computed axial tomography; computer tomography; computerized axial tomography; computerized tomography; Translating; Osseointegration; Businesses; Case Series; base; improved; Area; Surface; Clinical; Phase; long bone; Failure; tool; Life; Torque; mechanical; Mechanics; Radius; Radial; Source; Width; Medical center; bone preservation; Performance; success; Animal Models and Related Studies; model of animal; model organism; Animal Model; Finite Element Analyses; Finite Element Analysis; Outsourcing; austin; novel; Modeling; Manufacturer; Manufacturer Name; preventing; prevent; Load-Bearing; Loadbearing; Weight-Bearing; Weightbearing; Weight-Bearing state; Defect; Data; Data Element; Resolution; Small Business Innovation Research Grant; SBIR; Small Business Innovation Research; Process; sample fixation; Fixation; Development; developmental; Image; imaging; cost; healing; design; designing; efficacy evaluation; efficacy analysis; efficacy assessment; efficacy examination; evaluate efficacy; examine efficacy; bone quality; Outcome; cost effective; innovation; innovate; innovative; Resistance; resistant; clinical application; clinical applicability; Implant; prototype; commercialization; bone geometry; Geometry; Trauma patient; Osteoporotic; osteoporotic bone; safety and feasibility; Orthopedic Surgery
Phase II
Contract Number: 5R44AR079300-02Start Date: 9/20/2021 Completed: 8/31/2024
Phase II year
2023Phase II Amount
$210,522Public Health Relevance Statement:
PROJECT NARRATIVE The threaded screws used in orthopaedic surgery share a common buttress design that has intrinsic weaknesses, potentially increasing the risk of postoperative complications. OsteoCentric has developed a novel thread-interface technology designated Bone Interlocking Thread Geometry (BITG) which seeks to mitigate these weaknesses. We have sought to optimize BITG after validating a bone-thread-interface Finite Element model. This SBIR Phase II proposal will continue with design optimization, followed by a large animal model study and optimization of the manufacturing methodology for the new thread geometry.
Project Terms:
Activities of everyday life; daily living function; daily living functionality; functional ability; functional capacity; Activities of Daily Living; Anatomic Sites; Anatomic structures; Anatomy; Animals; Architecture; Engineering / Architecture; bone; Bone Screws; Clinical Research; Clinical Study; cost effectiveness; Education; Educational aspects; Elements; Equipment; Face; faces; facial; Fatigue; Lack of Energy; Fracture; bone fracture; Future; Patient Care; Patient Care Delivery; Goals; Healthcare Systems; Health Care Systems; Histology; Human; Modern Man; Israel; Lead; Pb element; heavy metal Pb; heavy metal lead; Marketing; Methods; Methodology; Study models; Orthopedics; Orthopedic; Orthopedic Surgical Profession; Patients; Postoperative Complications; post-operative complications; Production; research and development; Development and Research; R & D; R&D; Risk; Sheep; Ovine; Ovis; Stress; Technology; Testing; X-Ray Computed Tomography; CAT scan; CT X Ray; CT Xray; CT imaging; CT scan; Computed Tomography; Tomodensitometry; X-Ray CAT Scan; X-Ray Computerized Tomography; Xray CAT scan; Xray Computed Tomography; Xray computerized tomography; catscan; computed axial tomography; computer tomography; computerized axial tomography; computerized tomography; non-contrast CT; noncontrast CT; noncontrast computed tomography; Translating; Osseointegration; Businesses; Case Series; improved; Area; Surface; Clinical; Phase; long bone; Failure; tool; Life; Torque; Mechanics; mechanic; mechanical; Radial; Radius; Source; Width; Medical center; bone preservation; Performance; success; Animal Model; Animal Models and Related Studies; model of animal; Finite Element Analysis; Finite Element Analyses; Outsourcing; austin; novel; Modeling; Manufacturer; preventing; prevent; Load Bearing; Weight Bearing; Weight-Bearing state; Defect; Data; Data Element; Resolution; resolutions; Small Business Innovation Research Grant; SBIR; Small Business Innovation Research; Process; sample fixation; Fixation; Development; developmental; Image; imaging; cost; healing; designing; design; determine efficacy; efficacy analysis; efficacy assessment; efficacy determination; efficacy examination; evaluate efficacy; examine efficacy; efficacy evaluation; bone quality; Outcome; cost effective; innovate; innovative; innovation; resistant; Resistance; clinical applicability; clinical application; Implant; prototype; commercialization; bone geometry; Geometry; Trauma patient; Osteoporotic; osteoporotic bone; safety and feasibility; Orthopedic Surgery; manufacture