
Novel Glucose Responsive Insulin for Improved Treatment of DiabetesAward last edited on: 7/19/2022
Sponsored Program
SBIRAwarding Agency
NIH : NIDDKTotal Award Amount
$300,000Award Phase
2Solicitation Topic Code
847Principal Investigator
Pawel FludzinskiCompany Information
AmideBio LLC
331 South 104th Street Uni 110
Louisville, CO 80027
Louisville, CO 80027
(303) 604-0296 |
info@amidebio.com |
www.amidebio.com |
Location: Single
Congr. District: 02
County: Boulder
Congr. District: 02
County: Boulder
Phase I
Contract Number: 1R43DK126521-01A1Start Date: 3/1/2021 Completed: 2/28/2023
Phase I year
2021Phase I Amount
$183,955Public Health Relevance Statement:
NARRATIVE Diabetes is rapidly becoming a global health crisis. In both Type I and Type II diabetics glycemic control is paramount as the inability to maintain glycemic control results in a number of secondary complications including neuropathy, nephropathy and retinopathy, that often lead to amputations, dialysis and blindness. A reversible glucose responsive insulin (GRI) would represent a significant improvement in diabetes care for both T1D and T2D patients. The success of this project will result in clinical candidates that will ultimately supplant basal and prandial insulins while simultaneously improving glycemic control and reducing hypoglycemic incidences known to increase cardiovascular risk as well as secondary complications.
Project Terms:
Adult ; 21+ years old ; Adult Human ; adulthood ; Amputation ; Binding Sites ; Combining Site ; Reactive Site ; Biological Assay ; Assay ; Bioassay ; Biologic Assays ; Blood Glucose ; Blood Sugar ; Calorimetry ; Clinical Trials ; Computing Methodologies ; computational methodology ; computational methods ; computer based method ; computer methods ; computing method ; Diabetes Mellitus ; diabetes ; Insulin-Dependent Diabetes Mellitus ; Brittle Diabetes Mellitus ; IDDM ; Juvenile-Onset Diabetes Mellitus ; Ketosis-Prone Diabetes Mellitus ; Sudden-Onset Diabetes Mellitus ; T1 DM ; T1 diabetes ; T1D ; T1DM ; Type 1 Diabetes Mellitus ; Type 1 diabetes ; Type I Diabetes Mellitus ; insulin dependent diabetes ; juvenile diabetes ; juvenile diabetes mellitus ; ketosis prone diabetes ; type I diabetes ; type one diabetes ; Non-Insulin-Dependent Diabetes Mellitus ; Adult-Onset Diabetes Mellitus ; Ketosis-Resistant Diabetes Mellitus ; Maturity-Onset Diabetes Mellitus ; NIDDM ; Non-Insulin Dependent Diabetes ; Noninsulin Dependent Diabetes ; Noninsulin Dependent Diabetes Mellitus ; Slow-Onset Diabetes Mellitus ; Stable Diabetes Mellitus ; T2 DM ; T2D ; T2DM ; Type 2 Diabetes Mellitus ; Type 2 diabetes ; Type II Diabetes Mellitus ; Type II diabetes ; adult onset diabetes ; ketosis resistant diabetes ; maturity onset diabetes ; type 2 DM ; type II DM ; type two diabetes ; Dialysis procedure ; Dialysis ; dialysis therapy ; Fructose ; Levulose ; Glucose ; D-Glucose ; Dextrose ; Goals ; Human ; Modern Man ; Hypoglycemia ; hypoglycemic ; hypoglycemic episodes ; Incidence ; Insulin ; Humulin R ; Novolin R ; Regular Insulin ; Insulin Infusion Systems ; insulin pump ; Kidney Diseases ; Nephropathy ; Renal Disease ; kidney disorder ; renal disorder ; Lead ; Pb element ; heavy metal Pb ; heavy metal lead ; Leucine ; Ligands ; Maintenance ; Methods ; Methodology ; Molecular Conformation ; Molecular Configuration ; Molecular Stereochemistry ; conformation ; conformational state ; Mutation ; Genetic Alteration ; Genetic Change ; Genetic defect ; genome mutation ; Pancreas ; Pancreatic ; Legal patent ; Patents ; Patients ; Production ; Proteins ; Insulin Receptor ; Insulin Receptor Protein-Tyrosine Kinase ; Insulin-Dependent Tyrosine Protein Kinase ; Retinal Diseases ; Retinal Disorder ; retina disease ; retina disorder ; retinopathy ; Somatomedins ; Insulin-Like Growth Factors ; Sulfation Factor ; insulinlike growth factor ; Testing ; Thermodynamics ; Thermodynamic ; Time ; Toxicology ; Trees ; Valine ; L-Valine ; Xylose ; D-Xylose ; carbene ; methylene ; Measures ; insulin Wakayama ; Caring ; base ; improved ; Phase ; Physiological ; Physiologic ; Series ; Screening procedure ; screening tools ; insight ; diabetic ; analog ; Diabetes Complications ; Diabetes-Related Complications ; Diabetic Complications ; Complications of Diabetes Mellitus ; milligram ; neuropathic ; Neuropathy ; System ; vision loss ; visual loss ; Blindness ; Receptor Protein ; receptor ; receptor bound ; receptor binding ; success ; Cryo-electron Microscopy ; Electron Cryomicroscopy ; cryo-EM ; cryoEM ; Cryoelectron Microscopy ; novel ; vigilance ; cardiovascular risk ; cardiovascular risk factor ; Property ; response ; QSAR ; Quantitiative Structure Activity Relationship ; Quantitative Structure-Activity Relationship ; Molecular Interaction ; Binding ; small molecule ; IGF1 ; IGFI ; IGF1 gene ; global health ; Affinity ; Data ; in vivo ; Ligand Binding ; Monitor ; Characteristics ; Process ; Development ; developmental ; computerized tools ; computational tools ; design ; designing ; glycemic control ; Coupled ; healthy volunteer ; type I diabetic ; type 1 diabetic ; standard of care ; lead series ; drug candidate ; phase 2 study ; phase II study ; screening ; biophysical properties ; biophysical characteristics ; biophysical characterization ; biophysical measurement ; biophysical parameters ; clinical candidate ; lead candidate ; machine learning algorithm ; machine learned algorithm ; euglycemia ; web server ; computational platform ; computing platform ; Type 2 diabetic ; Type II diabetic ; pharmacokinetics and pharmacodynamics ; PK/PD ; in silico ; Rapid screening ;
Phase II
Contract Number: 5R43DK126521-02Start Date: 3/1/2021 Completed: 2/28/2023
Phase II year
2022Phase II Amount
$116,045Public Health Relevance Statement:
NARRATIVE Diabetes is rapidly becoming a global health crisis. In both Type I and Type II diabetics glycemic control is paramount as the inability to maintain glycemic control results in a number of secondary complications including neuropathy, nephropathy and retinopathy, that often lead to amputations, dialysis and blindness. A reversible glucose responsive insulin (GRI) would represent a significant improvement in diabetes care for both T1D and T2D patients. The success of this project will result in clinical candidates that will ultimately supplant basal and prandial insulins while simultaneously improving glycemic control and reducing hypoglycemic incidences known to increase cardiovascular risk as well as secondary complications.
Project Terms:
Adult ; 21+ years old ; Adult Human ; adulthood ; Amputation ; Binding Sites ; Combining Site ; Reactive Site ; Biological Assay ; Assay ; Bioassay ; Biologic Assays ; Blood Glucose ; Blood Sugar ; Calorimetry ; Clinical Trials ; Computing Methodologies ; computational methodology ; computational methods ; computer based method ; computer methods ; computing method ; Diabetes Mellitus ; diabetes ; Insulin-Dependent Diabetes Mellitus ; Brittle Diabetes Mellitus ; IDDM ; Juvenile-Onset Diabetes Mellitus ; Ketosis-Prone Diabetes Mellitus ; Sudden-Onset Diabetes Mellitus ; T1 DM ; T1 diabetes ; T1D ; T1DM ; Type 1 Diabetes Mellitus ; Type 1 diabetes ; Type I Diabetes Mellitus ; insulin dependent diabetes ; juvenile diabetes ; juvenile diabetes mellitus ; ketosis prone diabetes ; type I diabetes ; type one diabetes ; Non-Insulin-Dependent Diabetes Mellitus ; Adult-Onset Diabetes Mellitus ; Ketosis-Resistant Diabetes Mellitus ; Maturity-Onset Diabetes Mellitus ; NIDDM ; Non-Insulin Dependent Diabetes ; Noninsulin Dependent Diabetes ; Noninsulin Dependent Diabetes Mellitus ; Slow-Onset Diabetes Mellitus ; Stable Diabetes Mellitus ; T2 DM ; T2D ; T2DM ; Type 2 Diabetes Mellitus ; Type 2 diabetes ; Type II Diabetes Mellitus ; Type II diabetes ; adult onset diabetes ; ketosis resistant diabetes ; maturity onset diabetes ; type 2 DM ; type II DM ; type two diabetes ; Dialysis procedure ; Dialysis ; dialysis therapy ; Levulose ; Fructose ; D-Glucose ; Dextrose ; Glucose ; Goals ; Modern Man ; Human ; hypoglycemic ; hypoglycemic episodes ; Hypoglycemia ; Incidence ; Humulin R ; Novolin R ; Regular Insulin ; Insulin ; insulin pump ; Insulin Infusion Systems ; Nephropathy ; Renal Disease ; kidney disorder ; renal disorder ; Kidney Diseases ; Pb element ; heavy metal Pb ; heavy metal lead ; Lead ; Leucine ; Ligands ; Maintenance ; Methods ; Methodology ; Molecular Configuration ; Molecular Stereochemistry ; conformation ; conformational state ; Molecular Conformation ; Genetic Alteration ; Genetic Change ; Genetic defect ; genome mutation ; Mutation ; Pancreatic ; Pancreas ; Patents ; Legal patent ; Patients ; Production ; Proteins ; Insulin Receptor Protein-Tyrosine Kinase ; Insulin-Dependent Tyrosine Protein Kinase ; Insulin Receptor ; Retinal Disorder ; retina disease ; retina disorder ; retinopathy ; Retinal Diseases ; Insulin-Like Growth Factors ; Sulfation Factor ; insulinlike growth factor ; Somatomedins ; Testing ; Thermodynamics ; Thermodynamic ; Time ; Toxicology ; Trees ; L-Valine ; Valine ; D-Xylose ; Xylose ; carbene ; methylene ; Measures ; insulin Wakayama ; Caring ; base ; improved ; Phase ; Physiological ; Physiologic ; Series ; Screening procedure ; screening tools ; insight ; diabetic ; analog ; Diabetes Complications ; Diabetes-Related Complications ; Diabetic Complications ; Complications of Diabetes Mellitus ; milligram ; neuropathic ; Neuropathy ; System ; vision loss ; visual loss ; Blindness ; receptor ; Receptor Protein ; receptor binding ; receptor bound ; success ; Cryoelectron Microscopy ; Cryo-electron Microscopy ; Electron Cryomicroscopy ; cryo-EM ; cryoEM ; novel ; vigilance ; cardiovascular risk factor ; cardiovascular risk ; Property ; response ; Quantitative Structure-Activity Relationship ; QSAR ; Quantitiative Structure Activity Relationship ; Binding ; Molecular Interaction ; small molecule ; IGF1 gene ; IGF1 ; IGFI ; global health ; Affinity ; Data ; in vivo ; Ligand Binding ; Monitor ; Characteristics ; Process ; developmental ; Development ; computational tools ; computerized tools ; designing ; design ; glycemic control ; Coupled ; healthy volunteer ; type 1 diabetic ; type I diabetic ; standard of care ; lead series ; drug candidate ; phase II study ; phase 2 study ; screening ; biophysical characteristics ; biophysical characterization ; biophysical measurement ; biophysical parameters ; biophysical properties ; clinical candidate ; lead candidate ; machine learned algorithm ; machine learning algorithm ; euglycemia ; web server ; computing platform ; computational platform ; Type II diabetic ; Type 2 diabetic ; PK/PD ; pharmacokinetics and pharmacodynamics ; in silico ; Rapid screening ;