
A New Class of Magnetic Nanoparticles for Glioma Targeted Drug DeliveryAward last edited on: 1/24/2022
Sponsored Program
STTRAwarding Agency
NIH : NCITotal Award Amount
$400,000Award Phase
1Solicitation Topic Code
395Principal Investigator
Yuancheng LiCompany Information
Phase I
Contract Number: 1R41CA261544-01Start Date: 7/20/2021 Completed: 6/30/2022
Phase I year
2021Phase I Amount
$400,000Project Terms:
Blood ; Blood Reticuloendothelial System ; Blood Circulation ; Bloodstream ; Circulation ; Brain Neoplasms ; Brain Neoplasia ; Brain Tumors ; tumors in the brain ; Malignant Neoplasms ; Cancers ; Malignant Tumor ; malignancy ; neoplasm/cancer ; Cell Death ; necrocytosis ; Cells ; Cell Body ; Charge ; Chemistry ; Combination Drug Therapy ; Polychemotherapy ; combination chemotherapy ; combination pharmacotherapy ; combined drug therapy ; Pharmaceutical Preparations ; Drugs ; Medication ; Pharmaceutic Preparations ; drug/agent ; ethylene glycol ; 1,2-Ethanediol ; 2-Hydroxyethanol ; Dihydroxyethanes ; Ethanediols ; Ethylene Glycols ; Monoethylene Glycol ; Glioblastoma ; Grade IV Astrocytic Neoplasm ; Grade IV Astrocytic Tumor ; Grade IV Astrocytoma ; glioblastoma multiforme ; spongioblastoma multiforme ; Glioma ; Glial Cell Tumors ; Glial Neoplasm ; Glial Tumor ; Neuroglial Neoplasm ; Neuroglial Tumor ; glial-derived tumor ; neuroglia neoplasm ; neuroglia tumor ; Goals ; Half-Life ; In Vitro ; Integrins ; Integrins Extracellular Matrix ; Lead ; Pb element ; heavy metal Pb ; heavy metal lead ; Ligands ; Liposomes ; Liposomal ; Magnetic Resonance Imaging ; MR Imaging ; MR Tomography ; MRI ; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance ; NMR Imaging ; NMR Tomography ; Nuclear Magnetic Resonance Imaging ; Zeugmatography ; Methods ; Mus ; Mice ; Mice Mammals ; Murine ; Legal patent ; Patents ; Patients ; Cyclic Peptides ; Drug Kinetics ; Pharmacokinetics ; Play ; Polymers ; Radiation therapy ; Radiotherapeutics ; Radiotherapy ; radiation treatment ; radio-therapy ; treatment with radiation ; Role ; social role ; Safety ; Technology ; Tissues ; Body Tissues ; Universities ; Water ; Hydrogen Oxide ; RGD (sequence) ; Arg-Gly-Asp ; Arginine-Glycine-Aspartic Acid Cell Adhesion Domain ; RGD Cell Adhesion Domain ; RGD Domain ; RGD Motif ; RGD Tripeptide Sequence ; RGD peptide ; RGD tripeptide ; arginyl-glycyl-aspartic acid ; glycidyl ethers ; Ultrafine ; Drug Delivery Systems ; Drug Delivery ; irinotecan ; Campto ; camptosar ; Malignant neoplasm of brain ; Brain Cancer ; Malignant Tumor of the Brain ; Iron deficiency anemia ; analytical method ; base ; density ; Organ ; tumor progression ; cancer progression ; neoplasm progression ; neoplastic progression ; improved ; Surface ; Clinical ; Encapsulated ; Malignant - descriptor ; Malignant ; Phase ; Biological ; uptake ; chemical property ; Oncology ; Oncology Cancer ; Therapeutic ; Therapeutic Agents ; Morphology ; Malignant Cell ; cancer cell ; Nature ; Investigation ; Clinic ; subdermal ; subcutaneous ; System ; Operative Procedures ; Surgical ; Surgical Interventions ; Surgical Procedure ; surgery ; Operative Surgical Procedures ; amphiphilicity ; biocompatibility ; biomaterial compatibility ; Lytotoxicity ; cytotoxicity ; physical property ; success ; water solubility ; Hydrophobicity ; tumor growth ; Toxicities ; Toxic effect ; Reporting ; Abscission ; Extirpation ; Removal ; Surgical Removal ; resection ; Excision ; chemotherapeutic agent ; Property ; Integrin aVBeta3 ; Integrin alpha-v beta-3 ; Integrin αVβ3 ; aVBeta3 ; alpha-v beta-3 Integrin Receptors ; Integrin alphaVbeta3 ; Clinical Oncology ; image-based method ; imaging method ; imaging modality ; preventing ; prevent ; nano medicinal ; nano medicine ; nanomedicinal ; nanomedicine ; Feraheme ; ferumoxytol ; Reproducibility ; in vivo ; Clinical Management ; Small Business Technology Transfer Research ; STTR ; Preparation ; Development ; developmental ; Intracranial Neoplasms ; Intracranial Central Nervous System Neoplasms ; Intracranial Central Nervous System Tumors ; Intracranial Tumor ; efficacy evaluation ; efficacy analysis ; efficacy assessment ; efficacy examination ; evaluate efficacy ; examine efficacy ; nanomaterials ; nano materials ; nanocarrier ; nano carrier ; nanoparticle ; nano particle ; nano-sized particle ; nanosized particle ; Biodistribution ; Outcome ; targeted delivery ; site targeted delivery ; chemotherapy ; mouse model ; murine model ; stem ; tumor ; overexpression ; overexpress ; FDA approved ; standard care ; standard treatment ; Systems Development ; theranostics ; Drug Targeting ; in vivo imaging ; imaging in vivo ; contrast enhanced ; Magnetic nanoparticles ; contrast imaging ; targeted biomarker ; Formulation ; novel drug class ; new drug class ; clinical translation ; nanoparticle delivery ; nano particle delivery ; nanoparticle delivered ; Nano delivery ; Nanodelivery ; iron oxide nanoparticle ; iron oxide nano particle ; side effect ; pharmacokinetics and pharmacodynamics ; PK/PD ; Chemotherapy and/or radiation ; Chemotherapy and Radiation ; blood-brain tumor barrier ; blood-tumor barrier ; bloodbrain tumor barrier ; blood-brain barrier crossing ; BBB crossing ; bloodbrain barrier crossing ; brain tumor imaging ; therapeutically effective ; Prognosis ;
Phase II
Contract Number: ----------Start Date: 00/00/00 Completed: 00/00/00