Over the last two decades, our laboratory has characterized adaptive changes in resting statebrain network synchrony in substance dependent individuals with long-term (multi-year)abstinence (LTA) from alcohol and drugs. These adaptive changes more than reverse networkresting-state synchrony (RSS) differences that are associated with active substance dependence(i.e., increased appetitive drive network RSS and decreased inhibitory control and emotion-regulation network RSS). We have also shown that EEG coherence based indices reflect thesesame networks in the same individuals. We have recently implemented real-time 64-channelEEG coherence-based network synchrony neurofeedback (NFB) to train the brain to mimic thechanges that occur with LTA. This Phase I SBIR effort will provide 12 such NFB sessions over a8 week period to opioid dependent individuals receiving Sublocade injection Medication AssistedTreatment (MAT). Matched pairs of subjects will be studied with a cross-over design, with half ofsubjects receiving NFB followed by a 8 week follow-up, and their counterparts being on a 8 weekwaiting list followed by NFB. The non-NFB intervals allows us to estimate normal RSS changeswithout NFB and measure the persistence of NFB effects.
Public Health Relevance Statement: Project Narrative Our laboratory has characterized the changes in brain network function that occur with multi-year abstinence from alcohol and drugs. 1. Lessening of the compulsive impulse to consume drugs in response to environmental stimuli; 2 Strengthening the individual's ability to inhibit unwanted behavior; 3 An increased ability to process (especially negative) emotions. We recently implemented real-time 64-channel EEG coherence-based network synchrony neurofeedback (NFB) to train the brain to mimic the changes that occur with multi-year abstinence.
Project Terms: Emotions ; Goals ; Growth ; Generalized Growth ; Tissue Growth ; ontogeny ; Impulsive Behavior ; indexing ; Laboratories ; Maintenance ; Maps ; Outpatients ; Out-patients ; Patients ; Public Health ; Rest ; Saline ; Saline Solution ; Scalp structure ; Scalp ; Seeds ; Plant Embryos ; Plant Zygotes ; seed ; Substance Addiction ; Substance Dependence ; Substance Use Disorder ; Technology ; Time ; Treatment Protocols ; Treatment Regimen ; Treatment Schedule ; Waiting Lists ; waitlist ; Measures ; Injectable ; base ; Clinical ; Phase ; Training ; increased appetite ; Appetite stimulated ; Increased food appetite ; increased hunger ; Stimulus ; Individual ; Drug usage ; drug use ; Crossover Design ; Cross-Over Designs ; Funding ; Phase II Clinical Trials ; Phase 2 Clinical Trials ; phase II protocol ; Attenuated ; Functional MRI ; fMRI ; Functional Magnetic Resonance Imaging ; Frequencies ; Clinic ; Protocol ; Protocols documentation ; Pattern ; System ; Opiate Dependence ; opioid addiction ; opioid dependence ; opioid dependent ; Opiate Addiction ; abstaining from alcohol ; abstaining from ethanol ; abstinence from alcohol ; abstinence from ethanol ; ethanol abstinence ; alcohol abstinence ; Study Subject ; Drug Exposure ; Impulsivity ; Emotional ; Sampling ; response ; Intervention Strategies ; interventional strategy ; Intervention ; Small Business Innovation Research Grant ; SBIR ; Small Business Innovation Research ; Process ; follow-up ; Active Follow-up ; active followup ; follow up ; followed up ; followup ; Development ; developmental ; Evidence based treatment ; cost ; clinical efficacy ; Outcome ; Consumption ; cognitive neuroscience ; Alcoholism ; National Institute on Alcohol Abuse and Alcoholism ; NIAAA ; Abstinence ; Network-based ; reward processing ; emotion regulation ; emotional regulation ; neurofeedback ; Compulsive Behavior ; opioid use disorder ; opiate use disorder ; medication-assisted treatment ; opioid use ; opiate consumption ; opiate drug use ; opiate intake ; opiate use ; opioid consumption ; opioid drug use ; opioid intake ; relapse risk ; Injections ; multimodal data ; multi-modal data ; multi-modal datasets ; multimodal datasets ; COVID-19 ; COVID19 ; CV-19 ; CV19 ; corona virus disease 2019 ; coronavirus disease 2019 ; data fusion ; functional magnetic resonance imaging/electroencephalography ; fMRI/EEG ; coronavirus disease ; COVID ; CoV disease ; corona virus disease ; alcohol use disorder ; ethanol use disorder ; Amplifiers ; Desire for food ; Appetite ; Behavior ; Brain ; Brain Nervous System ; Encephalon ; Buprenorphine ; comorbidity ; co-morbid ; co-morbidity ; Cues ; Pharmaceutical Preparations ; Drugs ; Medication ; Pharmaceutic Preparations ; drug/agent ; Electrodes ; Electroencephalography ; EEG ;
