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A microED pipeline for the pharmaceutical and biotechnology industryAward last edited on: 5/20/2023
Sponsored Program
SBIRAwarding Agency
NIH : NIGMSTotal Award Amount
$1,402,767Award Phase
2Solicitation Topic Code
859Principal Investigator
Giovanna ScapinCompany Information
NanoImaging Services Inc
4940 Carroll Canyon Road Suite 115
San Diego, CA 92121
San Diego, CA 92121
(888) 675-8261 |
info@nanoimagingservices.com |
www.nanoimagingservices.com |
Location: Single
Congr. District: 52
County: San Diego
Congr. District: 52
County: San Diego
Phase I
Contract Number: N/AStart Date: 6/1/2021 Completed: 5/31/2023
Phase I year
2021Phase I Amount
$1Phase II
Contract Number: 1R44GM140666-01Start Date: 6/1/2021 Completed: 5/31/2023
Phase II year
2021(last award dollars: 2022)
Phase II Amount
$1,402,766Public Health Relevance Statement:
Narrative High-resolution structures of proteins, small molecules and their complexes are a critical part of the drug discovery process collectively known as Structure-Based Drug Design (SBDD) in the pharmaceutical and biotechnology industries. MicroED is an emerging structural technique that will support advancement of human health through enabling novel molecular targets for chemotherapies and new biologics. NanoImaging Services (NIS) proposes to build upon an initial microED service offering to deliver an expanded suite of services aligned with the unique needs of the industrial market, addressing reproducibility, throughput, affordability, speed, and flexibility.
Project Terms:
Acetaminophen ; APAP ; Acetamidophenol ; Acetominophen ; Hydroxyacetanilide ; Paracetamol ; Algorithms ; Automation ; Biotechnology ; Biotech ; Biotin ; Vitamin H ; coenzyme R ; Pharmaceutical Chemistry ; Medicinal Chemistry ; Pharmaceutic Chemistry ; Client ; Commercial Sectors ; Crystallization ; Data Collection ; Drug Design ; Pharmaceutical Preparations ; Drugs ; Medication ; Pharmaceutic Preparations ; drug/agent ; Feedback ; Goals ; Health ; Human ; Modern Man ; Industrialization ; Industry ; Handedness ; Laterality ; Maps ; Methods ; Online Systems ; On-Line Systems ; online computer ; web based ; Peptides ; Progesterone ; Corpus Luteum Hormone ; Delta4-pregnene-3,20-dione ; Pregn-4-ene-3,20-dione ; Pregnenedione ; Therapeutic Progesterone ; Proteins ; Research ; Rotation ; Computer software ; Software ; Specificity ; statistics ; Testing ; Time ; Work ; Drug Costs ; Data Set ; Dataset ; base ; Microscope ; Electron Microscope ; improved ; Procedures ; Phase ; Biological ; Series ; X-Ray Crystallography ; Single Crystal Diffraction ; X Ray Crystallographies ; X-Ray Diffraction Crystallography ; X-Ray/Neutron Crystallography ; Xray Crystallography ; Ensure ; data quality ; Robot ; Research Specimen ; Specimen ; Knowledge ; programs ; Hour ; Complex ; Event ; Clinic ; Techniques ; System ; 3-D ; 3D ; three dimensional ; 3-Dimensional ; interest ; Services ; chiral molecule ; Speed ; Structure ; novel ; Modeling ; Sampling ; Property ; drug development ; drug discovery ; data processing ; computerized data processing ; Pharmaceutical Agent ; Pharmaceuticals ; Pharmacological Substance ; Pharmacologic Substance ; small molecule ; Address ; Data ; Molecular Target ; Reproducibility ; Resolution ; Collection ; transmission process ; Transmission ; Preparation ; Molecular ; Process ; Development ; developmental ; Image ; imaging ; nanoimaging ; nano imaging ; cost ; novel strategies ; new approaches ; novel approaches ; novel strategy ; three dimensional structure ; 3-D structure ; 3-dimensional structure ; 3D structure ; data acquisition ; chemotherapy ; flexibility ; flexible ; data reduction ; screening ; targeted treatment ; targeted drug therapy ; targeted drug treatments ; targeted therapeutic ; targeted therapeutic agents ; targeted therapy ; electron diffraction ; crystallinity ; Natural Products ; improved outcome ; microscopic imaging ; microscope imaging ; microscopy imaging ; Structural Protein ; Micro Electron Diffraction ; MicroEd ; data analysis pipeline ; data processing pipeline ;