This Phase I SBIR will develop a microfabricated breath biomarker analyzer. There is an unmetneed for easy-to-use, cost-effective, miniature devices for rapid, specific, and sensitive analysisof breath biomarkers, especially volatile organic compounds (VOCs). The proposed analyzer isbuilt on high-performance MEMS (microelectromechanical systems) gas chromatography (GC)columns. A preliminary study demonstrated the MEMS column's high separation efficiency andspeed, and developed a functional prototype of one-dimensional micro GC with a single MEMScolumn. In this Phase I study, the MEMS column technology will be adopted to develop amicrofabricated comprehensive two-dimensional GC (micro GCxGC), so as to significantlyimprove the separation power of micro GC and address the need for breath VOCbiomarker/profile analysis. Phase I specific aims are to create a prototype sampling device forextraction and preconcentration of breath VOCs, demonstrate GCxGC with two MEMS columnshaving orthogonal selectivity for breath VOCs on a benchtop GC, and create a proof-of-conceptprototype of the proposed MEMS column based breath VOC analyzer.The proposed product aims to address the unmet need for point-of-need breath biomarkerstudies. It is expected to have wide applications for personal exposure assessment and healthstatus monitoring.
Public Health Relevance Statement: Project Narrative
There is an unmet need for point-of-need breath biomarker analysis. The proposed micro
analyzer aims to address the unmet need and provide a non-invasive, non-hazardous tool for
personal exposure assessment and health status monitoring.
Project Terms: Acetone ; 2-Propanone ; Dimethyl formaldehyde ; Air ; Alcohols ; Alcohol Chemical Class ; Aldehydes ; Anesthetics ; Anesthestic Drugs ; Anesthetic Agents ; Anesthetic Drugs ; Asthma ; Bronchial Asthma ; Breath Tests ; breath analysis ; Calibration ; Carbon Dioxide ; CO2 ; Carbonic Anhydride ; Cardiovascular Diseases ; cardiovascular disorder ; Gas Chromatography ; vapor phase chromatography ; Cities ; Cystic Fibrosis ; Mucoviscidosis ; Diabetes Mellitus ; diabetes ; Diagnosis ; Diet ; diets ; Environmental Exposure ; Environmental Pollution ; environmental contaminant ; environmental contamination ; Gases ; Health Status ; Level of Health ; Hydrocarbons ; Ketones ; Chronic Obstructive Airway Disease ; COPD ; Chronic Obstruction Pulmonary Disease ; Chronic Obstructive Lung Disease ; Chronic Obstructive Pulmonary Disease ; Mass Fragmentography ; GC MS ; GCMS ; Gas-Liquid-Mass Spectrometry Chromatography ; Mass Fragmentographies ; Mass-Gas Chromatography Spectrometry ; Mass-Gas Chromatography Spectrum Analysis ; ion trap mass spectrometry ; mass fragmentometry ; Methods ; Nose ; Nasal ; Nasal Passages Nose ; Respiratory System, Nose, Nasal Passages ; Research ; Resources ; Research Resources ; Mass Spectrum Analysis ; Mass Photometry/Spectrum Analysis ; Mass Spectrometry ; Mass Spectroscopy ; Mass Spectrum ; Mass Spectrum Analyses ; Technology ; Testing ; Tuberculosis ; M tuberculosis infection ; M. tb infection ; M. tuberculosis infection ; M.tb infection ; M.tuberculosis infection ; MTB infection ; Mycobacterium tuberculosis (MTB) infection ; Mycobacterium tuberculosis infection ; TB infection ; disseminated TB ; disseminated tuberculosis ; infection due to Mycobacterium tuberculosis ; tuberculosis infection ; tuberculous spondyloarthropathy ; Virginia ; Work ; Generations ; base ; sensor ; improved ; Phase ; Chemicals ; Evaluation ; Individual ; Agricultural Workers ; agriculture worker ; Malignant neoplasm of lung ; Malignant Tumor of the Lung ; Pulmonary Cancer ; Pulmonary malignant Neoplasm ; lung cancer ; Measurement ; Letters ; Zebra ; Exposure to ; tool ; Disorder Management ; Disease Management ; Adopted ; Dimensions ; System ; metal oxide ; Performance ; Speed ; skills ; Column Chromatography ; Devices ; Reporting ; Sampling ; Address ; Detection ; Collection ; Small Business Innovation Research Grant ; SBIR ; Small Business Innovation Research ; Validation ; Monitor ; Development ; developmental ; cost effective ; two-dimensional ; 2-dimensional ; volatile organic compound ; volatile organic chemical ; prototype ; FDA approved ; Biological Markers ; bio-markers ; biologic marker ; biomarker ; phase 1 study ; Phase I Study ; ventilator-associated pneumonia ; ventilator-acquired pneumonia ; detection test ; detection tests ; coal-fired power plant ; coal power plant ; fire fighter ; fire services ; firefighter ;
