
High Throughput Screen and High Information Follow-Up Tests for GenotoxicantsAward last edited on: 4/26/2023
Sponsored Program
SBIRAwarding Agency
NIH : NIEHSTotal Award Amount
$1,832,396Award Phase
2Solicitation Topic Code
113Principal Investigator
Stephen D DertingerCompany Information
Litron Laboratories (AKA: Litron Laboratories Ltd)
Location: Single
Congr. District: 25
County: Monroe
Congr. District: 25
County: Monroe
Phase I
Contract Number: 1R44ES033138-01Start Date: 4/3/2021 Completed: 3/31/2022
Phase I year
2021Phase I Amount
$204,743Project Terms:
Biological Assay ; Assay ; Bioassay ; Biologic Assays ; Buffers ; Canada ; Malignant Neoplasms ; Cancers ; Malignant Tumor ; malignancy ; neoplasm/cancer ; Cell Line ; CellLine ; Strains Cell Lines ; cultured cell line ; Cell Nucleus ; Nucleus ; Cells ; Cell Body ; Data Analyses ; Data Analysis ; data interpretation ; Statistical Data Interpretation ; Statistical Data Analyses ; Statistical Data Analysis ; statistical analysis ; Disease ; Disorder ; DNA Damage ; DNA Injury ; DNA Repair ; DNA Damage Repair ; Unscheduled DNA Synthesis ; Elements ; Environment ; Exhibits ; Experimental Designs ; Flow Cytometry ; Flow Cytofluorometries ; Flow Cytofluorometry ; Flow Microfluorimetry ; Flow Microfluorometry ; flow cytophotometry ; Goals ; Health ; Histone H3 ; Human ; Modern Man ; In Vitro ; Industry ; instrumentation ; Metabolic Activation ; Methods ; micronucleus ; Microspheres ; Microbeads ; Miniaturization ; Miniaturisations ; Modernization ; Mutagenicity Tests ; Genetic Toxicity Tests ; Genotoxicity Tests ; Mutagen Screening ; mutagen testing ; Mutagens ; Genotoxins ; genotoxic agent ; Protease Inhibitor ; Antiproteases ; Endopeptidase Inhibitors ; Peptidase Inhibitors ; Peptide Hydrolase Inhibitors ; Peptide Peptidohydrolase Inhibitors ; Protease Antagonists ; Proteinase Inhibitors ; Reagent ; Recommendation ; Sensitivity and Specificity ; Temperature ; Testing ; Time ; Toxicology ; Work ; Measures ; TP53 gene ; Antioncogene Protein p53 ; Cellular Tumor Antigen P53 ; Oncoprotein p53 ; P53 ; Phosphoprotein P53 ; Phosphoprotein pp53 ; Protein TP53 ; TP53 ; TRP53 ; Tumor Protein p53 ; Tumor Protein p53 Gene ; p53 Antigen ; p53 Genes ; p53 Tumor Suppressor ; protein p53 ; Risk Assessment ; Data Set ; Dataset ; base ; improved ; Phase ; Chemicals ; Training ; Logistics ; Measurement ; machine learned ; Machine Learning ; programs ; Frequencies ; cell type ; Techniques ; System ; Nuclear ; Lytotoxicity ; cytotoxicity ; Performance ; phosphatase inhibitor ; genotoxicity ; Speed ; Reporting ; Coding System ; Code ; Modeling ; Sampling ; response ; High Throughput Assay ; high throughput screening ; Endpoint Assays ; End Point Assay ; Genetic Toxicology ; Toxicology Genetics ; Toxicogenetics ; preventing ; prevent ; Address ; Dose ; Animal Testing ; DNA Double Strand Break ; Data ; Mitotic ; Collection ; Scheme ; Validation ; Characteristics ; Process ; follow-up ; Active Follow-up ; active followup ; follow up ; followed up ; followup ; Development ; developmental ; National Toxicology Program ; computerized tools ; computational tools ; design ; designing ; climate change ; global climate change ; blind ; innovation ; innovate ; innovative ; prototype ; Biological Markers ; bio-markers ; biologic marker ; biomarker ; screening ; Formulation ; response biomarker ; response markers ; experimental study ; experiment ; experimental research ; testing services ;
Phase II
Contract Number: 4R44ES033138-02Start Date: 4/8/2022 Completed: 3/31/2024
Phase II year
2022(last award dollars: 2023)
Phase II Amount
$1,627,653Public Health Relevance Statement:
Project Narrative Some chemicals in commercial use and in the environment can cause DNA damage and this damage can contribute to the development of cancer and other severe diseases. We will develop, optimize, and validate an improved testing strategy based on highly automated processes tracking several DNA damage biomarkers that can be analyzed without the need for animal testing. These methods will be configured into commercially available kits and testing services.
Project Terms: