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Nanoparticles for Detecting Noradrenergic Neurons in Alzheimer's DiseaseAward last edited on: 5/5/2023
Sponsored Program
STTRAwarding Agency
NIH : NIATotal Award Amount
$266,683Award Phase
1Solicitation Topic Code
866Principal Investigator
Puliyur MohankumarCompany Information
Phase I
Contract Number: 1R41AG069539-01Start Date: 8/15/2020 Completed: 7/31/2021
Phase I year
2020Phase I Amount
$266,683Public Health Relevance Statement:
Proposal narrative: The proposal aims to develop imaging modalities that can monitor changes in brainstem using a novel nanoparticle-based imaging agent. This nanoparticle is small enough to cross the blood brain barrier and is actively taken up by catecholaminergic neurons. It has the capacity to transform how neurological and psychological disorders are diagnosed, monitored and treated. Specifically, this will help monitor the locus coeruleus, a noradrenergic area of the brain, which shows the earliest pathological changes in Alzheimer's disease.
Project Terms:
Affect; Age; age related; Alzheimer's Disease; Alzheimer's disease model; American; Amino Acid Neurotransmitters; Amyloid beta-Protein; Anabolism; Animal Model; Area; Arousal; Basal Nucleus of Meynert; base; Behavioral; Biological; biomaterial compatibility; Biopsy; Blood - brain barrier anatomy; Brain; Brain imaging; Brain Stem; Cannulas; Caregivers; Catecholamines; Cerebral cortex; Characteristics; cholinergic; Cognition; Cognitive; Cognitive deficits; Contrast Media; cost effective; Cost of Illness; design; Diagnosis; Disease; Disease Progression; Early Diagnosis; Early treatment; Economic Burden; economic impact; Functional disorder; Goals; Healthcare Systems; High Pressure Liquid Chromatography; hindbrain; Hippocampus (Brain); Human; Human Amyloid Precursor Protein; Image; imaging agent; imaging capabilities; imaging modality; implantation; innovation; Levodopa; Ligands; locus ceruleus structure; Magnetic Resonance Imaging; Magnetism; Measures; Memory Loss; Mental disorders; Methods; Modality; Monitor; mutant; nanoparticle; Nanostructures; Near-infrared optical imaging; Nerve Degeneration; nerve supply; nervous system disorder; neurobehavioral; Neurocognitive; Neurocognitive Deficit; Neurodegenerative Disorders; Neurofibrillary Tangles; Neurons; Neurotransmitters; non-invasive imaging; non-invasive monitor; noradrenergic; Norepinephrine; novel; Operative Surgical Procedures; Optics; Outcome; particle; Pathologic; Pathology; Patients; Phase; Phenylalanine; Positron-Emission Tomography; Pre-Clinical Model; Preclinical Testing; presenilin-1; Process; Property; Prosencephalon; Quality of life; Rattus; Research; Resolution; Sampling; Small Business Technology Transfer Research; Structure; tau Proteins; temporal measurement; Testing; Thalamic structure; Therapeutic Intervention; Three-Dimensional Imaging; Tissues; tool; Translating; Wakefulness
Phase II
Contract Number: ----------Start Date: 00/00/00 Completed: 00/00/00