Comprehensive Reagents for Immunophenotyping Rabbit Cell-Mediated Immunity
Award last edited on: 6/18/2021

Sponsored Program
Awarding Agency
Total Award Amount
Award Phase
Solicitation Topic Code
Principal Investigator
Natalie Castellana

Company Information

Abterra Biosciences Inc (AKA: Digital Proteomics LLC~Abterra Biosciences Inc)

3030 Bunker Hill Street Suite 218
San Diego, CA 92109
   (888) 416-9305
Location: Single
Congr. District: 50
County: San Diego

Phase I

Contract Number: 75N93020C00023
Start Date: 00/00/00    Completed: 00/00/00
Phase I year
Phase I Amount
Infectious disease studies in tuberculosis and papillomavirus have shown humans and rabbits share similar pathology and rabbits are more phylogenetically similar to primates than rodents. The use of the rabbit model is hindered by the lack of species-specific immunological reagents. In this proposal, we will take a rational approach to generate the most critical reagents that are essential for sorting and in vitro culture of subsets of immune cells (B, T and NK cells, monocytes and granulocytes) to adaptively boost the development of a practical panel of reagents for comprehensive profiling of the rabbit cell-mediated immunity. The proposal will discover antibodies to detect cell surface markers on rabbit B and T cells. Negative selection of the dominant B and T cell populations will better resolve other immune cells types (NK cells) and provides opportunity to find new cell surface markers to develop antibodies against. The proposed work will evaluate discovery of single variable domain antibodies to serve as versatile reagents in a comprehensive immunophenotyping panel that can be formatted for flow cytometry, immunostaining, and cell isolation.

Phase II

Contract Number: ----------
Start Date: 00/00/00    Completed: 00/00/00
Phase II year
Phase II Amount