
Dual Electron-Based Fragmentation with Ion Mobility to Advance Native Top-Down ProteomicsAward last edited on: 9/26/2022
Sponsored Program
SBIRAwarding Agency
NIH : NIGMSTotal Award Amount
$1,716,549Award Phase
2Solicitation Topic Code
859Principal Investigator
Valery G VoinovCompany Information
Phase I
Contract Number: 1R43GM134792-01Start Date: 9/1/2019 Completed: 3/31/2020
Phase I year
2019Phase I Amount
$223,899Public Health Relevance Statement:
Even with all of the scientific progress made to date, the complexity of disease-affected tissues still challenges our ability to probe what makes people sick. The goal of this Phase I SBIR project is to develop a powerful tool for more effectively cutting biological molecules into identifiable fragments that will improve the diagnosis and treatment of diseases ranging from arthritis, cancer and diabetes to heart disease and neurodegeneration.
Project Terms:
Address; Adoption; Affect; Agreement; Antibodies; Arthritis; base; Biological; Businesses; Capillary Electrophoresis; Cardiovascular Diseases; Cell Mobility; Cells; Charge; Cleaved cell; Complex; cost effective; crosslink; design; Diabetes Mellitus; Diagnosis; Disease; Dissociation; Disulfides; electron energy; Electron Transport; Electrons; Filament; fly; Fourier transform ion cyclotron resonance; Funding; Gases; glycosylation; Goals; Heart Diseases; Hour; improved; Inflammation; instrument; instrumentation; ion mobility; Ions; Isoleucine; lens; Leucine; macromolecule; magnetic field; Malignant Neoplasms; Marketing; mass spectrometer; Mass Spectrum Analysis; Methodology; Methods; Modernization; Nerve Degeneration; Nitrogen; Noble Gases; Pattern; Peptide Fragments; Peptides; Phase; Phosphorylation; Post-Translational Protein Processing; preservation; pressure; prevent; protein complex; Protein Fragment; Proteins; Proteomics; rapid technique; Reaction; Research Personnel; Resolution; Sampling; Side; Small Business Innovation Research Grant; Speed; Techniques; Technology; Testing; Tissues; tool; Travel; Trypsin; United States National Institutes of Health; Water; Work
Phase II
Contract Number: 2R44GM134792-02Start Date: 9/1/2019 Completed: 3/31/2022
Phase II year
2020(last award dollars: 2021)
Phase II Amount
$1,492,650Public Health Relevance Statement:
Project narrative:
Even with all of the scientific progress made to date, the complexity of disease- affected tissues still challenges our ability to probe what makes people sick. The goal of this Phase II SBIR project is to develop a powerful tool for characterize biological molecules into identifiable fragments that will improve the diagnosis and treatment of diseases ranging from arthritis, cancer, diabetes to heart disease and neurodegeneration.
Project Terms:
Address; Adoption; Affect; Alcohol dehydrogenase; Antibodies; Arthritis; Aspartate; base; Behavior; beta-Aspartate; Biological; Biological Products; Businesses; Capsid; Cardiovascular Diseases; Cell physiology; Cell Separation; Cells; Charge; Communities; Complex; Computer software; Congestive; cost effective; design; Development; Devices; Diabetes Mellitus; Diagnosis; Dimensions; Disease; Dissociation; Electron Transport; Electronics; Electrons; Erythrocytes; Family; Feasibility Studies; Filament; flexibility; fly; Future; Goals; Heart Diseases; Hemoglobin; Hour; Human; improved; Inflammation; instrument; instrumentation; interest; ion mobility; Ions; Isoleucine; Laboratories; Leucine; Location; Macromolecular Complexes; macromolecule; Malignant Neoplasms; mass spectrometer; Mass Spectrum Analysis; Methodology; Methods; Modernization; Multiprotein Complexes; Nerve Degeneration; Noble Gases; operation; Pattern; Peptides; Periodicity; Phase; phase 1 study; Physiologic pulse; Post-Translational Protein Processing; preservation; Problem Solving; Process; Protein Analysis; protein complex; Protein Fragment; Proteins; Proteomics; prototype; Research Personnel; Resolution; Side; Small Business Innovation Research Grant; software development; Speed; Stream; success; Technology; Testing; Tissues; tool; transmission process; Travel; Trypsin; United States National Institutes of Health; Variant; Vendor; Viral; Water; Work