
Ultra-Bright Fluorescent Probes for Flow CytometryAward last edited on: 2/2/2021
Sponsored Program
SBIRAwarding Agency
NIH : NIGMSTotal Award Amount
$1,549,882Award Phase
2Solicitation Topic Code
100Principal Investigator
Jiangbo YuCompany Information
Phase I
Contract Number: 1R43GM126848-01Start Date: 9/20/2017 Completed: 6/19/2018
Phase I year
2017Phase I Amount
$149,800Public Health Relevance Statement:
Project Narrative Flow cytometry is a high throughput technology that is extensively employed in biology and medicine for quantifying cellular features, cell lineages, and cell signaling pathways. Some applications of flow cytometry include the cell cycle and surface analysis of cancers, monitoring the progression of AIDS and the response to treatment by measuring CD4 lymphocyte levels in blood, the study of surface markers of lymphomas and leukemias, and characterization of immune cells for immuno-therapy and precision medicine, all of which are of significant value for diagnostics and prognostics. This proposal aims to develop a new class of reagents for flow cytometry.
Project Terms:
absorption; Acquired Immunodeficiency Syndrome; Antigens; base; Biological Sciences; Biology; Biomedical Research; Blood; CD4 Positive T Lymphocytes; Cell Cycle; Cell Lineage; Cell surface; Cells; Characteristics; Chemicals; design; Development; Diagnosis; Diagnostic; Dyes; Energy Transfer; Exhibits; Family; Financial compensation; Flow Cytometry; Fluorescence; Fluorescent Dyes; Fluorescent Probes; fluorophore; Goals; high throughput technology; Hospitals; Immune; Immunotherapy; indexing; Institution; instrument; interest; Label; Lasers; leukemia/lymphoma; Malignant Neoplasms; Measures; Medical center; Medicine; Modernization; Monitor; Motivation; nanoparticle; outcome forecast; Particle Size; Performance; Phase; Photons; Phycoerythrin; Play; Polymers; precision medicine; prognostic; Protocols documentation; Publications; Quality Control; quantum; Reagent; Reporting; Research; Series; Signal Pathway; Signal Transduction; Staining method; Stains; stem; success; Surface; Time; treatment response; two-photon; Universities; Vertebral column; Viola; Water; Width; Work
Phase II
Contract Number: 2R44GM126848-02Start Date: 9/20/2017 Completed: 7/31/2020
Phase II year
2018(last award dollars: 2020)
Phase II Amount
$1,400,082Thesaurus Terms:
Absorption; Acquired Immunodeficiency Syndrome; Antigens; Base; Biological Sciences; Biology; Blood; Cancer Biomarkers; Cd4 Positive T Lymphocytes; Cell Cycle; Cell Lineage; Cell Surface; Cells; Characteristics; Chemicals; Design; Development; Diagnostic; Dyes; Energy Transfer; Exhibits; Family; Financial Compensation; Flow Cytometry; Fluorescence; Fluorescent Dyes; Fluorescent Probes; High Throughput Technology; Immune; Immunotherapy; Instrument; Interest; Label; Lasers; Leukemia/Lymphoma; Malignant Neoplasms; Measures; Medicine; Modernization; Monitor; Motivation; Nanoparticle; Particle Size; Performance; Phase; Photons; Phycoerythrin; Polymers; Precision Medicine; Prognostic; Protocols Documentation; Publications; Quality Control; Quantum; Quantum Dots; Reagent; Reporting; Series; Signal Pathway; Signal Transduction; Stem; Success; Surface; Time; Treatment Response; Two-Photon; Ultraviolet; Vertebral Column; Viola; Water; Width; Work;