Metastasis of aggressive breast cancer is a devastating and ultimately fatal condition. The current drugs which are used to treat breast cancer focus on the reduction of the tumor size and have proven to be successful. However, currently there are no available treatment options which can effectively inhibit tumor invasion and metastasis. Novel drug strategies therefore are needed to treat this chronic, fatal and incurable condition. Our therapeutic strategy for the treatment of aggressive breast cancer is based on reducing Id-1 expression. In the Phase 1 segment of this Fast-Track proposal our focus will be on developing lead compounds that display a favorable in vivo profile. In Phase II segment of this proposal our lead compounds will be evaluated in multiple in vivo models. We will also develop leads that display a favorable ADME-Tox profile. The ultimate goal of this proposal is to develop a novel therapeutic approach for the treatment of metastatic human breast cancers by down-regulation of Id-1.
Public Health Relevance Statement: 8. Project Narrative Metastasis of aggressive breast cancer is a devastating and ultimately fatal condition. Currently there are no available treatment options which can effectively inhibit tumor invasion and metastasis. The goal of this proposal is to develop a non-toxic medication for the treatment and prevention of metastatic breast cancer.
Project Terms: abstracting; Acute; Adverse effects; analog; base; BHLH Protein; Breast; Breast Cancer Cell; Breast cancer metastasis; cancer cell; Cannabidiol; Cannabinoids; carcinogenesis; Cell Line; Cells; Cessation of life; Chronic; Clinical; clinical practice; Complement; cytotoxic; cytotoxicity; Development; Disseminated Malignant Neoplasm; Dose; Down-Regulation; Doxorubicin; Drug Kinetics; Gene Expression; Gene Targeting; Goals; Growth; Helix-Turn-Helix Motifs; Human; in vivo; in vivo Model; inhibitor/antagonist; Isomerism; Lead; Licensing; malignant breast neoplasm; Malignant Neoplasms; MDA MB 231; Metastatic breast cancer; Modeling; Neoplasm Metastasis; neoplastic cell; Normal Cell; novel therapeutic intervention; novel therapeutics; Outcome; Paclitaxel; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Pre-Clinical Model; preclinical study; Prevention; Process; Program Development; programs; Property; Proteins; Rattus; Resistance; Resources; Route; scale up; Staging; Structure; targeted agent; Testing; Therapeutic; Therapeutic Intervention; Time; Tissues; Toxic effect; Toxicology; treatment strategy; triple-negative invasive breast carcinoma; tumor; Tumor Cell Invasion; tumor progression; Work
