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Superficially Porous Silica Based Chiral Stationary Phases for High Efficiency and High Speed Pharmaceutical Analysis and PurificationAward last edited on: 9/14/2017
Sponsored Program
SBIRAwarding Agency
NIH : NIGMSTotal Award Amount
$972,200Award Phase
2Solicitation Topic Code
-----Principal Investigator
Jauh Tzuoh LeeCompany Information
AZYP LLC
700 Planetarium Place CRB Room 303
Arlington, TX 76019
Arlington, TX 76019
(817) 272-1399 |
questions@azypusa.com |
www.azypusa.com |
Location: Single
Congr. District: 06
County: Tarrant
Congr. District: 06
County: Tarrant
Phase I
Contract Number: ----------Start Date: ---- Completed: ----
Phase I year
2016Phase I Amount
$486,100Public Health Relevance Statement:
Public Health Relevance:
Pharmaceutical compounds that are chiral (from the Greek word for "hand") can exist as enantiomers (i.e., right and left-handed versions of the same basic compound) and for medicines of this sort, usually one enantiomer (either the right or left-handed version) is the drug, while the other half causes side effects, different effects, similar effects r in limited cases, no effects. In our proposed research we introduce a new technology for the analysis and purification of chiral drugs which utilizes specialized packing materials called superficially porous particle based chiral stationary phases, which in our feasibility studies proved to offer the ability to reduce chiral drug analysis times from tens of minutes to tens of seconds by greatly increasing the efficiency of the analysis and improving the ability to rapidly, separate and purify most classes of chiral pharmaceutical compounds, as well as, other biologically relevant chiral molecules. As a result of this proposed work, Americans will have better and less expensive pharmaceutical products that have fewer side effects and can be given in lower doses, and scientists will have better means to study stereo selective effects of chiral biological molecules.
Project Terms:
Accounting; Adverse effects; American; Area; base; Biological; chiral molecule; Chromatography; Column Chromatography; commercialization; Complex; Cyclodextrins; Development; Dose; enantiomer; Ensure; Evaluation; Feasibility Studies; Funding; Future; Greek; Growth; Hand; High Pressure Liquid Chromatography; improved; innovative technologies; Left; Liquid substance; Marketing; Medicine; Methods; molecular recognition; Neck; new technology; North America; novel; Organic Chemistry; particle; Performance; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Play; Preclinical Drug Evaluation; Preparation; Procedures; Process; Production; prototype; public health relevance; Reproducibility; Research; Resolution; Role; Sales; scale up; Scientist; screening; Secure; Silicon Dioxide; Small Business Innovation Research Grant; Solid; Sorting - Cell Movement; Speed (motion); stability testing; success; Surface; Technology; Teicoplanin; Testing; Time; tool; Vancomycin; Work
Phase II
Contract Number: ----------Start Date: ---- Completed: ----
Phase II year
2017Phase II Amount
$486,100Public Health Relevance Statement:
Public Health Relevance:
Pharmaceutical compounds that are chiral (from the Greek word for "hand") can exist as enantiomers (i.e., right and left-handed versions of the same basic compound) and for medicines of this sort, usually one enantiomer (either the right or left-handed version) is the drug, while the other half causes side effects, different effects, similar effects r in limited cases, no effects. In our proposed research we introduce a new technology for the analysis and purification of chiral drugs which utilizes specialized packing materials called superficially porous particle based chiral stationary phases, which in our feasibility studies proved to offer the ability to reduce chiral drug analysis times from tens of minutes to tens of seconds by greatly increasing the efficiency of the analysis and improving the ability to rapidly, separate and purify most classes of chiral pharmaceutical compounds, as well as, other biologically relevant chiral molecules. As a result of this proposed work, Americans will have better and less expensive pharmaceutical products that have fewer side effects and can be given in lower doses, and scientists will have better means to study stereo selective effects of chiral biological molecules.
Project Terms:
Adverse effects; American; Area; base; Biological; chiral molecule; Chromatography; Column Chromatography; commercialization; Complex; Cyclodextrins; Development; Dose; enantiomer; Ensure; Evaluation; Feasibility Studies; Funding; Future; Greek; Growth; Hand; High Pressure Liquid Chromatography; improved; innovative technologies; Left; Marketing; Medicine; Methods; molecular recognition; Neck; new technology; North America; novel; Optics; Organic Chemistry; particle; Performance; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Play; Preclinical Drug Evaluation; Preparation; Procedures; Process; Production; prototype; public health relevance; Reproducibility; Research; Resolution; Role; Sales; scale up; Scientist; screening; Secure; Silicon Dioxide; Small Business Innovation Research Grant; Solid; Speed; stability testing; success; Supercritical Fluid Chromatography; Surface; Technology; Teicoplanin; Testing; Time; tool; Vancomycin; Work