Harmonus Inc. is proposing to develop a patientspecific disposable tool for directing needle entry during MRIguided prostate biopy. Prostate cancer is the second leading cause of cancer death in the U.S. Over 225,000 cases of cancer were diagnosed in 2014 with almost 30,000 deaths. Prostate cancer is treatable, if properly diagnosed. By accurately targeting MRIvisible regions suspected of containing cancer, our system will improve the ability to find lifethreatening tumors and reducethe chance of unnecessarily treating lowrisk cases compared to current methods. Fabrication will be based on a rapid, precision machine for creating the guide from a sterile ki. In Phase I we will (I) Develop and demonstrate our novel method for producing the guides and (2) Verify that the manufacturing process maintains sterility of the guide. The product, after successful applications in biopsies, can be extended for use in other MRIguided procedures and treatments for prostate cancer.
Public Health Relevance Statement: Public Health Relevance: Harmonus Inc. is proposing to develop a patientspecific needle guide for directing needle entry during MRIguided prostate biopsy. The proposed research will benefit public health by improving patient quality of life through increased identification of aggressive cancer, reduced overtreatment of nonaggressive tumors and reduced biopsy complications associated with current prostate biopsy methods. Our approach will reduce infection risk and will be less expensive than robotic systems offered as alternatives
Project Terms: Address; Antibiotics; Apical; Bacteria; base; Biopsy; cancer diagnosis; Cancer Etiology; Cessation of life; Clinical; cost; Custom; design; Devices; Diagnosis; Diagnostic; Dimensions; Discipline; Dose; drug resistant bacteria; Elasticity; Elements; Engineering; Ensure; experience; Fostering; Generations; Health; Hospitals; image guided; Image Guided Biopsy; Imaging Phantoms; imaging software; improved; Infection; Investments; Life; Location; Magnetic Resonance Imaging; Malignant neoplasm of prostate; Malignant Neoplasms; Manufacturer Name; manufacturing process; Medical Device; Medical Imaging; member; Methods; Nature; Needles; novel; Patients; Phase; Positioning Attribute; Procedures; Process; programs; prophylactic; Prostate; prostate biopsy; Public Health; Quality of life; rectal; Rectum; Research; research and development; Research Personnel; Resolution; Risk; Robot; robotic device; Robotics; Sampling; Scanning; skills; Small Business Innovation Research Grant; Sterility; success; System; Techniques; Technology; tool; Transrectal Ultrasound; tumor; Ultrasonography; Welding; Woman; Work
