SBIR-STTR Award

Nanotechnology-Based Environmental Smart Sensors for Personal Health Exposure Monitoring
Award last edited on: 11/6/2019

Sponsored Program
SBIR
Awarding Agency
NIH : NIEHS
Total Award Amount
$190,000
Award Phase
1
Solicitation Topic Code
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Principal Investigator
Krishna Naishadham

Company Information

Wi-Sense LLC

405 Oak Brook Court SE
Smyrna, GA 30082
   (770) 573-0584
   N/A
   www.wisensewearables.com
Location: Single
Congr. District: 13
County: Cobb

Phase I

Contract Number: ----------
Start Date: ----    Completed: ----
Phase I year
2016
Phase I Amount
$150,000
?A broad goal of the proposed research is to develop personal exposure monitors comprising wearable, wireless sensor arrays to detect harmful air pollutants within the breathing zone, and improve the assessment of causative exposure-dose-response relationships in epidemiological studies. Heterogeneous orthogonal detectors comprising functionalized carbon nanotube (CNT) based resonators will be designed and integrated with a smart phone platform, targeting the detection of ambient ozone (O3) in Phase 1, particulate matter, NOx and VOCs in Phase 2. Ozone not only influences climatic changes globally through greenhouse gas emissions, but also produces adverse health effects in humans as a secondary pollutant in urban smog through precursors generated in traffic and industrial pollution. As a powerful oxidant gas, O3 can elicit a range of physiological responses once inhaled, including reduced lung function and inflamed airways, exacerbating respiratory diseases such as asthma. Numerous research efforts address the relationship between ozone exposure and health outcomes including mortality and morbidity (hospitalizations, decrements in lung function, and asthma status), but due to lack of personal exposure data, considerable error may be introduced in assessing dose-response relationships. Currently, there are no existing sensors in the market suitable for real- time O3 exposure measurement within the breathing zone. Phase 1 research develops an ozone exposure detector array, fabricated using two classes of nanosensors: (a) polybutadiene polymer-functionalized CNT thin-films, (b) CNT thin-films decorated with Pt or Pd metallic nanoparticles. Both offer maximum sensitivity to ozone while reducing cross-sensitivity to interferents such as NOx. These detector films are integrated with compact radio-frequency (RF) resonators, which respond with unique resonance shift caused by molecular level gas adsorption on the film interface. In contrast to a chemiresistor, both amplitude and frequency shifts in this RF nanosensor may be used to minimize false positives for robust discrimination. Differential signaling between the primary sensor and a reference sensor (pure CNTs) compensates for environmental factors such as humidity, further improving selectivity. The differential signal is wirelessly interfaced through a microcontroller t a smart phone for data display of concentration levels and data communication to public health professionals or regulatory bodies via participatory and ubiquitous sensing. Additionally, sensors embedded in the mobile phone yield information on motion, physical activity, time stamp and GPS location of the subject that can be correlated to the exposure. A prototype O3 sensor will be developed and its performance characterized under controlled laboratory and ambient conditions. Field tests will be conducted on human volunteers to detect ambient ozone as a function of time over several days, and results compared directly with measurements made by standard badge samplers. Causative relationships will be explored by measuring eNO concentrations following the exposure, in collaboration with an environmental epidemiologist.

Public Health Relevance Statement:
PUBLIC HEALTH RELEVANCE : The importance of the proposed ozone sensors with regard to public health is highlighted by the fact that EPA's stringent National Ambient Air Quality Standard (NAAQS) for ozone emission levels are exceeded in many parts of the US, and there is a tremendous need to better characterize the spatial and temporal distributions of ozone. The proposed research has significant potential to reduce health care costs by enhancing the understanding of causative exposure-dose respiratory health effects through improved accuracy and enhanced population size in public health studies. In conjunction with embedded sensors such as 3D accelerometers, heart rate, respiration rate, fitness tracking, and many more existing or proposed smart phone utilities, the proposed mobile personal exposure monitors can potentially enhance epidemiological population studies and gather rich metadata on environmental pollutants, and their exposure effects on humans, as a function of location, season and physical activity. The long-term vision of the proposed work (Phase 2 and beyond) is to develop reliable low-cost sensors to simultaneously measure the external exposure to multiple environmental pollutants, and integrate these chemical sensors with biosensors for measuring the levels of toxicants in biological specimens obtained from an individual, such as blood, saliva, exhaled breath, sweat or urine. Thus, the exposure measurements of the proposed sensor can be combined with diagnostic tools to assess an individual's internal dosage and physiological effects, thereby providing comprehensive exposure assessment from source to dose.

Project Terms:
Accelerometer; Address; Adsorption; Air; Air Pollutants; airway inflammation; ambient air pollution; Asthma; asthmatic; base; Biological; Biosensor; Blood; Breathing; Car Phone; Carbon Nanotubes; Cellular Phone; Chemicals; Climate; Collaborations; Communication; cost; Data; Data Display; design; Detection; detector; Development; Diagnostic; Diffusion; Discrimination (Psychology); dosage; Dose; Electronics; Ensure; Environment; Environmental Pollutants; Environmental Risk Factor; Epidemiologic Studies; Epidemiologist; Epidemiology; Evaluation; Exhalation; Exposure to; Feasibility Studies; field study; Film; fitness; Frequencies (time pattern); Gases; Goals; greenhouse gases; Health; Health Care Costs; Health Professional; Heart Rate; Hospitalization; Hour; Human; human subject; Human Volunteers; Humidity; improved; Individual; Laboratories; Learning; Life; Location; Lung diseases; Marketing; Measurement; Measures; meetings; Metadata; Molecular; Monitor; Morbidity - disease rate; Morphology; Mortality Vital Statistics; Motion; nanoparticle; nanosensors; Nanotechnology; Outcome; oxidant gases; Ozone; ozone exposure; Particulate Matter; Performance; personal exposure monitor; Phase; Physical activity; Physiological; Pilot Projects; pollutant; Pollution; polybutadiene; Polymers; Population Sizes; Population Study; Printing; prototype; public health medicine (field); public health relevance; Pump; radio frequency; Recruitment Activity; Relative (related person); Research; Respiration; respiratory health; Respiratory physiology; response; Saliva; Sampling; Seasons; sensor; Signal Transduction; Smog; Source; Specimen; Staging; stressor; Surface; Sweat; Sweating; Thick; Time; tool; toxicant; trafficking; Universities; Urine; Validation; Vision; Weight; Wireless Technology; Work

Phase II

Contract Number: ----------
Start Date: ----    Completed: ----
Phase II year
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Phase II Amount
$40,000