The objective of this Phase I STTR project is to demonstrate feasibility of developing a selective, affordable, and pocket-sized device to enable regular and quantitative monitoring of both Li+ and Na+ levels in the blood of patients with bipolar disorder (BD), which is one of the most common mental illnesses affecting over 6 million Americans, costing the healthcare system over $45 billion dollars annually. Even though lithium (Li+) therapy is one of the most effective and affordable long-term treatments for BD,
Public Health Relevance Statement: Project narrative Although lithium therapy is one of the most effective and affordable long-term treatments for bipolar disorder (BD), less than 25% of BD patients are prescribed with lithium drug in large part because of its very narrow therapeutic window (0.5 â 1.2 mM) between ineffectiveness or very severe side effects. By adapting widely available blood glucose meter and highly selective DNAzymes to detect lithium and sodium (whose level is related to lithium level in the blood), this STTR Phase I project will demonstrate feasibility of developing a novel, affordable and pocket-sized device to enable regular and quantitative monitoring of both Li+ and Na+ in the blood of BD patients. Accomplishing the goal will improve effective and wider use of Li+ therapy in BD patients by enabling more precise control of Li+ dosing, which will have a major impact in improving the lives of the patients with this common disorder and lowering their healthcare costs.
Project Terms: abstracting; Address; Adoption; Adult; Adverse effects; Affect; American; base; Bedside Testings; Binding; Biological Assay; Biological Markers; Bipolar Disorder; Blood; Blood Glucose; Catalysis; Catalytic DNA; Chicago; Clinical; Clinical Research; Collaborations; combinatorial; cost; design; Detection; Devices; Disease; DNA; DNA Library; Dose; Economic Burden; Ensure; Enzymes; Foundations; Glucose; glucose monitor; Goals; Health Care Costs; Healthcare Systems; Home environment; Hydrolysis; Illinois; improved; In Vitro; Individual; innovation; Invertase; Ions; Libraries; Life; Lithium; Measurement; Measures; Medical Device; Mental disorders; Metals; meter; Methods; Monitor; monitoring device; Mono-S; novel; Outcome; Patients; Performance; Pharmaceutical Preparations; Phase; phosphodiester; point of care; Point-of-Care Systems; Population; portability; Production; Proteins; prototype; Psyche structure; Reaction; Risk; Sampling; scale up; sensor; Signal Transduction; Small Business Technology Transfer Research; Sodium; Specificity; Structure; Sucrose; System; Technology; Testing; Therapeutic; Universities; user-friendly; Validation; Vertebral column; Wor
