SBIR-STTR Award

Epilepsy is a debilitating brain disorder and surgery is the key treatment modality for those patients whose seizures cannot be controlled medically. Epilepsy surgery is complex, requiring multimodal imaging data for planning and execution, and image analysis software is essential for this process. The overall goal of this application is to develop a robust commercial software platform for multimodal image analysis for epilepsy surgery that can obtain regulatory approval for clinical use in both academic and non- academic hospitals. These software tools were developed in part for the needs of our epilepsy research at Yale over the last 10 years under NIH/NIBIB funding and in part internally at Electrical Geodesics Inc. for the brain segmentation, source analysis, and display parts of the forthcoming GeoSource 3.0 software package. The innovation in this proposal lies (i) the development of innovative image analysis methodology that addresses specific needs in epilepsy image analysis and (ii) the translation of tested research software to a new design that will enable its successful transition via regulatory approval to clinical use. The significance of this proposal is that it aims to provide clinically usable epilepsy surgical planning software with explicit support for multimodal image integration and intracranial electrode localization that can be integrated with the image-guided navigation systems used for neurosurgery. This tool would have a major impact on both surgical planning and image-guided epilepsy neurosurgery.

Public Health Relevance Statement:


Public Health Relevance:
In the US, the lifetime cost of epilepsy for an estimated 181,000 people with an onset in 1995 is projected at $11.1B and the annual cost for an estimated 2.3 million prevalent cases is estimated at $12.5B. In many of these cases, the treatment procedure requires identifying the abnormal brain region involved and removing it via neurosurgery. Epilepsy surgery costs over $100,000 per case and since the surgery is complex and often involves two phases, image analysis software is critical to integrate multimodal imaging and EEG recording for pre- and intra-operative decision support.

Project Terms:
Accounting; Address; Affect; Archives; base; bioimaging; Brain; Brain Diseases; Brain region; brain surgery; Cephalic; Child; Clinical; Clinical Research; clinical research site; Code; Complex; Computer software; cost; Custom; Data; Databases; design; Development; Disease; Electrodes; Electroencephalography; Epilepsy; Excision; experience; Failure (biologic function); Functional Magnetic Resonance Imaging; Funding; Goals; Hospitals; Housing; Image; Image Analysis; image processing; image registration; Imagery; imaging modality; implantation; Implanted Electrodes; innovation; Intractable Epilepsy; Joints; Left; Licensing; Life; life time cost; Location; Magnetic Resonance Imaging; Maps; Measurement; Medical; Methodology; Methods; Modality; Multimodal Imaging; multimodality; National Institute of Biomedical Imaging and Bioengineering; Navigation System; neuroimaging; neurosurgery; open source; Operative Surgical Procedures; Patients; Pharmaceutical Preparations; Phase; Population; Positron-Emission Tomography; Postoperative Period; Procedures; Process; programs; public health relevance; Research; research clinical testing; Research Infrastructure; research study; Seizures; sharing data; Site; Small Business Innovation Research Grant; Software Tools; Solutions; Source; Surface; Techniques; Testing; Tissues; Tomography, Emission-Computed, Single-Photon; tool; Translations; United States National Institutes of Health; Work; X-Ray Computed Tomography

Epilepsy is a debilitating brain disorder and surgery is the key treatment modality for those patients whose seizures cannot be controlled medically. Epilepsy surgery is complex, requiring multimodal imaging data for planning and execution, and image analysis software is essential for this process. The overall goal of this application is to develop a robust commercial software platform for multimodal image analysis for epilepsy surgery that can obtain regulatory approval for clinical use in both academic and non- academic hospitals. These software tools were developed in part for the needs of our epilepsy research at Yale over the last 10 years under NIH/NIBIB funding and in part internally at Electrical Geodesics Inc. for the brain segmentation, source analysis, and display parts of the forthcoming GeoSource 3.0 software package. The innovation in this proposal lies (i) the development of innovative image analysis methodology that addresses specific needs in epilepsy image analysis and (ii) the translation of tested research software to a new design that will enable its successful transition via regulatory approval to clinical use. The significance of this proposal is that it aims to provide clinically usable epilepsy surgical planning software with explicit support for multimodal image integration and intracranial electrode localization that can be integrated with the image-guided navigation systems used for neurosurgery. This tool would have a major impact on both surgical planning and image-guided epilepsy neurosurgery.

Public Health Relevance Statement:


Public Health Relevance:
In the US, the lifetime cost of epilepsy for an estimated 181,000 people with an onset in 1995 is projected at $11.1B and the annual cost for an estimated 2.3 million prevalent cases is estimated at $12.5B. In many of these cases, the treatment procedure requires identifying the abnormal brain region involved and removing it via neurosurgery. Epilepsy surgery costs over $100,000 per case and since the surgery is complex and often involves two phases, image analysis software is critical to integrate multimodal imaging and EEG recording for pre- and intra-operative decision support.

Project Terms:
Accounting; Address; Affect; Archives; base; bioimaging; Brain; Brain Diseases; Brain region; brain surgery; Cephalic; Child; Clinical; Clinical Research; clinical research site; Code; Complex; Computer software; cost; Custom; Data; Databases; design; Development; Disease; Electrodes; Electroencephalography; Epilepsy; Excision; experience; Failure (biologic function); Functional Magnetic Resonance Imaging; Funding; Goals; Health; Hospitals; Housing; Image; Image Analysis; image guided; image processing; image registration; Imagery; imaging modality; implantation; Implanted Electrodes; innovation; Intractable Epilepsy; Joints; Left; Licensing; Life; life time cost; Location; Magnetic Resonance Imaging; Maps; Measurement; Medical; Methodology; Methods; Modality; Multimodal Imaging; multimodality; National Institute of Biomedical Imaging and Bioengineering; Navigation System; neuroimaging; neurosurgery; open source; Operative Surgical Procedures; Patients; Pharmaceutical Preparations; Phase; Population; Positron-Emission Tomography; Postoperative Period; Procedures; Process; programs; Research; research clinical testing; Research Infrastructure; research study; Seizures; sharing data; Site; Small Business Innovation Research Grant; Software Tools; Solutions; Source; Surface; Techniques; Testing; Tissues; Tomography, Emission-Computed, Single-Photon; tool; Translations; United States National Institutes of Health; Work; X-Ray Computed Tomography