The objective of this proposal is to design, develop, and validate a commercially viable "human-use" smart 128-channel macro & micro ECoG microsystem with integrated recording, stimulation, and impedance measuring capabilities for epilepsy monitoring. The microsystem comprises of a state-of-art microelectronic signal processing component linked to a macro & micro integrated ECoG grid via a thin, highly flexible, bio- compatible micro-ribbon cable on one end and a single percutaneous flexible-cable ("pigtail") on the other end. The custom multiplexing ASIC electronics is capable of 128-channel recordings at 16-bit resolution and has fast settle capability (for stimulation option) and patient safety circuitry. The component is contained on a printed circuit board and is encapsulated with Parylene-C and Silicone. The encapsulated microelectronic component unit is encased in a titanium case and resides subcutaneously between the skin and the skull. The integrated microsystem would have unique "snow-flake" shape grid design containing alternate rows of macro and micro channels. The phase-I would target a short-term goal of developing, bench testing and validating in adult sheep model the complete implantable ECoG microsystem that can be translated to research and clinical lab in the shortest time frame.
Public Health Relevance Statement: Public Health Relevance: The objective of this proposal is to design, develop, and validate a commercially viable "human-use" thin film polymer based smart 128-channel macro & micro integrated ECoG array system for epilepsy monitoring
NIH Spending Category: Assistive Technology; Bioengineering; Brain Disorders; Epilepsy; Neurodegenerative; Neurosciences
Project Terms: absorption; Adult; Aluminum Oxide; Amplifiers; Animal Model; Animals; Architecture; Area; Arts; awake; Back; base; Biocompatible; Blood Vessels; Chronic; Clinical; clinical practice; Clinical Research; Communities; cranium; Custom; Data; density; design; Development; Devices; digital; electric impedance; Electrodes; Electronics; Electrophysiology (science); Encapsulated; Engineering; Ensure; Epilepsy; Evaluation; Film; flexibility; Goals; Health; Histology; Human; Implant; implantable device; implantation; improved; In Situ; In Vitro; in vitro testing; in vivo; interest; Life; Link; Location; Longevity; Maps; Measurement; Measures; Mechanics; meetings; microsystems; Modeling; Monitor; nervous system disorder; novel; Operative Surgical Procedures; parylene; parylene C; patient safety; Patients; Phase; Platinum; Polychlorinated Biphenyls; Polymers; Printing; Process; Production; Research; Resistance; Resolution; Safety; Sampling; Shapes; Sheep; Shunt Device; Side; signal processing; Signal Transduction; Silicones; Site; Skin; Snow; Somatosensory Evoked Potentials; Specificity; Subdural space; Surface; System; Systems Integration; Testing; Thick; Time; Titania; Titanium; Tomography, Emission-Computed, Single-Photon; tool; Translating; Translations; Wireless Technology
