SBIR-STTR Award

High Throughput Data Collection Software for Multiplexed Tem Samples
Award last edited on: 11/5/14

Sponsored Program
SBIR
Awarding Agency
NIH : NIGMS
Total Award Amount
$223,243
Award Phase
1
Solicitation Topic Code
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Principal Investigator
Craig Kazuaki Yoshioka

Company Information

NanoImaging Services Inc

4940 Carroll Canyon Road Suite 115
San Diego, CA 92121
Location: Single
Congr. District: 52
County: San Diego

Phase I

Contract Number: 1R43GM108080-01A1
Start Date: 6/20/14    Completed: 6/19/15
Phase I year
2014
Phase I Amount
$223,243
Transmission electron microscopy is a valuable technique for characterizing biological therapeutics, vaccines, drug delivery vehicles, and nanoparticles. There is considerable evidence that links the physical properties of these samples to their bio-distribution, safety, and efficacy. TEM imaging allows direct observation and quantification of these parameters, which include size distributions, shape distributions, concentrations, aggregation states, and 2D and 3D structure determinations. This wealth of information is especially useful when researchers must troubleshoot problems of unknown origin. As bio-therapeutics and nanoparticles increase in size and complexity, TEM is becoming increasingly important as an orthogonal complement to other biophysical methods. Despite the obvious utility of TEM as a direct technique for describing the physicochemical properties of samples in a variety of relevant biological environments, the cost per sample is a significant barrier to the method's widespread adoption, particularly for routine screening of samples. To address this, we will develop software focused on high-throughput data acquisition of multiple samples applied to a single grid substrate. Our long-term goal is to lower the cost per sample for TEM by at least an order of magnitude, and thus establish TEM as an affordable and ubiquitous technique for commercial R&D and testing.

Thesaurus Terms:
Address;Adoption;Antibodies;Architecture;Automation;Base;Behavior;Benchmarking;Biodistribution;Biological;Biological Models;Biophysical Techniques;Complement;Computer Software;Cost;Data;Data Acquisition;Data Collection;Data Set;Design;Detection;Development;Documentation;Drug Delivery Systems;Ensure;Environment;Evaluation;Future;Generations;Goals;Health;Hour;Image;Image Processing;Improved;Link;Location;Measurement;Methods;Microscope;Monitor;Nanoparticle;Nanorod;Nanotechnology;Online Systems;Performance;Pharmacologic Substance;Phase;Physical Property;Predictive Modeling;Process;Property;Prototype;Public Health Relevance;Research And Development;Research Personnel;Resolution;Running;Safety;Sampling;Screening;Shapes;Software Development;Specific Qualifier Value;Specimen;Stress;System;Techniques;Technology;Testing;Therapeutic;Therapeutic Vaccine;Three Dimensional Structure;Time;Tool;Toxic Effect;Transmission Electron Microscopy;Vaccines;Virus;

Phase II

Contract Number: ----------
Start Date: 00/00/00    Completed: 00/00/00
Phase II year
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Phase II Amount
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