SBIR-STTR Award

The central dogma of molecular biology has undergone a significant revision where RNAs have emerged as important regulators of cell activity. Astonishingly, as much as 80% of human DNA is transcribed into RNA as recently reported by the Encyclopedia of DNA Elements (ENCODE) consortium. New classes of RNA are being identified including many which are non-protein coding (ncRNA). Nonetheless ncRNAs are involved in regulating cellular activity. Deciphering the structure-function relationship of these RNAs is of immediate importance as ncRNAs have now been implicated in a variety of diseases including myotonic dystrophy type 1, prostate cancer, spinal muscular atrophy, and Huntington's disease-like 2. Traditional approaches to determine high-resolution RNA 3D structures have proven to be prohibitively time consuming and expensive. Nymirum has developed an Automated RNA 3D Structure Determination System that is faster, cheaper, and more robust than current approaches. This System will be commercialized for use by the drug industry and academic researchers in their quest to understand and treat human disease.

Thesaurus Terms:
Cell Physiology;Cells;Chemicals;Cloud Based;Code;Complex;Computer Software;Crystallography;Custom;Databases;Disease;Drug Industry;Encyclopedia Of Dna Elements;Functional Rna;Human Disease;Human Dna;Human Genome;Huntington Disease;Improved;Industry;Innovation;Internet;Knowledge;Label;Licensing;Machine Learning;Malignant Neoplasm Of Prostate;Measures;Methods;Molecular Biology;Myotonic Dystrophy;Oligonucleotides;Online Systems;Pharmaceutical Preparations;Phase;Phosphoramidite;Public Health Relevance;Publishing;Reporting;Research Personnel;Resolution;Ribonucleosides;Rna;Sales;Small Business Innovation Research Grant;Spinal Muscular Atrophy;Structure;Structure-Activity Relationship;Success;System;Techniques;Technology;Testing;Three Dimensional Structure;Time;Training;Ultra High Resolution;Update;

The central dogma of molecular biology has undergone a significant revision where RNAs have emerged as important regulators of cell activity. Astonishingly, as much as 80% of human DNA is transcribed into RNA as recently reported by the Encyclopedia of DNA Elements (ENCODE) consortium. New classes of RNA are being identified including many which are non-protein coding (ncRNA). Nonetheless ncRNAs are involved in regulating cellular activity. Deciphering the structure-function relationship of these RNAs is of immediate importance as ncRNAs have now been implicated in a variety of diseases including myotonic dystrophy type 1, prostate cancer, spinal muscular atrophy, and Huntington's disease-like 2. Traditional approaches to determine high-resolution RNA 3D structures have proven to be prohibitively time consuming and expensive. Nymirum has developed an Automated RNA 3D Structure Determination System that is faster, cheaper, and more robust than current approaches. This System will be commercialized for use by the drug industry and academic researchers in their quest to understand and treat human disease.

Public Health Relevance Statement:


Public Health Relevance:
RNA 3D structure and function information is critical to understanding basic cell function, delineating dysfunctional RNA contribution to human disease, and finding new drugs to treat diseases caused by dysfunctional RNAs. Nymirum has developed an Automated RNA 3D Structure Determination System that is faster, cheaper, and more robust than current approaches.

NIH Spending Category:
Rare Diseases

Project Terms:
Cell physiology; Cells; Chemicals; cloud based; Code; Complex; Computer software; Crystallography; Custom; Databases; Disease; Drug Industry; Encyclopedia of DNA Elements; human disease; human DNA; Human Genome; Huntington Disease; improved; Industry; innovation; Internet; Knowledge; Label; Licensing; Machine Learning; Malignant neoplasm of prostate; Measures; Methods; Molecular Biology; Myotonic Dystrophy; Oligonucleotides; Online Systems; Pharmaceutical Preparations; Phase; phosphoramidite; public health relevance; Publishing; Reporting; Research Personnel; Resolution; Ribonucleosides; RNA; Sales; Small Business Innovation Research Grant; Spinal Muscular Atrophy; Structure; Structure-Activity Relationship; success; System; Techniques; Technology; Testing; three dimensional structure; Time; Training; ultra high resolution; Untranslated RNA; Update